: PI3K/Akt/mTOR signaling pathway: The major signal transduction involved in the anticancer effects of resveratrol

Article summary: PI3K/Akt/mTOR signaling pathway: The major signal transduction involved in the anticancer effects of resveratrol

This article is a review of research that has gathered evidence on the role of Resveratrol in inhibiting the onset and progression of cancer. Emphasis is placed on controlling the signal path. PI3K/Akt/mTOR It is one of the important mechanisms that control survival, division, and energy metabolism. and the spread of cancer cells

Importance of PI3K/Akt/mTOR in cancer

signal path PI3K/Akt/mTOR It is often overstimulated in many types of cancer. As a result, cancer cells can:

- Continuously increasing division

- Avoid cell death (Apoptosis)

- Stimulates the creation of new blood vessels to nourish the cancer tumor.

- Increases cancer invasion and spread.

- Easier to develop resistance to chemotherapy drugs

How does Resveratrol work against cancer?

According to many studies, Resveratrol can:

1. Inhibits the activity of PI3K, Akt and mTOR.

- Reduce signals that stimulate the growth of cancer cells.

- Slow down the cell division cycle.

2. Stimulate the death of cancer cells (Apoptosis)

- increases the activity of proteins that promote cell death

- Reduce proteins that help cancer cells survive.

3. Inhibits the spread of cancer

- Reduce the Epithelial-Mesenchymal Transition (EMT) process.

- Reduces the ability to move and invade cancer cells.

4. Inhibits the creation of new blood vessels. (Anti-angiogenesis)

- Causes the tumor to receive less nutrients and oxygen.

5. Increased sensitivity to treatment

- Helps cancer cells respond better to chemotherapy and other treatments.

Cancers in which the effects of Resveratrol are being studied

Positive results have been reported in many cancers including:

☆ Breast cancer

☆ Prostate cancer

☆ Colon cancer

☆ Lung cancer

☆ Stomach cancer

☆ Ovarian cancer

☆ Pancreatic cancer

☆ Glioblastoma brain cancer

☆ Melanoma skin cancer

Important conclusions of the article

The author concludes that PI3K/Akt/mTOR It is the main signaling pathway involved in Resveratrol's anticancer effects. Resveratrol can regulate several key points in this pathway. Resulting in the effect

● Resists the division of cancer cells.

● Stimulates the death of cancer cells.

● Inhibit the spread.

● Enhances the efficiency of cancer treatment in many forms.

Therefore, they are considered natural polyphenols with high potential to support cancer prevention and control through balancing the pathways. PI3K/Akt/mTOR comprehensively