MDPI (International Journal of Molecular Sciences)⁠ published an article titled “Resveratrol and Female Fertility: A Systemat...

MDPI (International Journal of Molecular Sciences)⁠ published “Resveratrol and Female Fertility: A Systematic Review” in 2024, reviewing 24 studies to evaluate the role of resveratrol in female fertility.

Brief summary

This research found that Resveratrol has the potential to help improve egg quality. ovarian function And may help increase your chance of getting pregnant. Especially in women who have problems such as

- age increases It causes egg quality to decrease.

- Polycystic Ovary Syndrome (PCOS)

- Premature Ovarian Insufficiency

- High oxidative stress (Oxidative Stress)

An important mechanism that increases fertility.

1. Effective antioxidants

Resveratrol reduces damage to egg cells from free radicals. This is an important factor that causes egg quality to decline with age.

2. Stimulates the SIRT1 gene

SIRT1 is involved in aging and energy production in the mitochondria. which is necessary for the development of healthy eggs

3. Increase the efficiency of mitochondria. It increases the production of ATP, which is the main energy source of egg cells. Makes eggs have better quality

4. Reduce inflammation and death of ovarian cells. Helps protect granulosa cells that play an important role in nurturing eggs.

5. Reduces androgens in PCOS patients, helping to improve ovulation and menstrual cycles in women with PCOS.

Results found in human studies From a study of women undergoing infertility treatment and In Vitro Fertilization:

● Better egg quality.

● Better embryo quality.

● The number of successfully fertilized eggs increases.

● The ovarian response to stimulation improves.

● Pregnancy rates and live birth rates have not increased consistently across studies.

Who is it suitable for?

■ Women aged 35 years and older whose egg quality begins to decline.

■ People with Polycystic Ovary Syndrome

■ People with low quality eggs.

■ People who are planning pregnancy or undergoing IVF/ICSI.

Important conclusions:

Resveratrol is a potent antioxidant that helps restore ovarian function. Increase egg quality and helps increase the chance of having children This is especially true in women who are older or have PCOS.