Review from the journal Heliyon: "A comprehensive review on the neuroprotective potential of resveratrol in ischemic ...

Summary of the Heliyon review article "A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke", summarizing key points about the role of resveratrol in ischemic stroke. "Resveratrol" can be used to protect the nervous system from ischemic stroke as follows:

1. What is resveratrol?

​It is a natural polyphenolic compound found in abundance in red grapes. and mulberry family plants Its outstanding properties are that it is a powerful antioxidant and anti-inflammatory.

2. Mechanism of action in protecting the brain (Neuroprotective Mechanisms)

When a cerebral ischemic stroke occurs The brain is deprived of blood and oxygen. leads to cell death The article states that resveratrol helps stop damage through several mechanisms:

- Antioxidants (Antioxidant): Helps reduce the creation of free radicals (ROS) and increase the level of antioxidant enzymes in the body.

- Anti-inflammatory (Anti-inflammation): Inhibits substances that cause inflammation, such as TNF-α and IL-1β, which destroy brain tissue after a stroke.

- Inhibition of cell death (Anti-apoptosis): Helps signal brain cells to withstand stress and not die too easily.

- Autophagy stimulation: helps cells get rid of damaged components. to maintain cell survival

- Protecting the blood-brain barrier (BBB Protection): Helps reduce leakage of the blood-brain barrier. This will help reduce brain swelling.

​3. Key Signaling Pathways

​The article emphasizes the activation of a receptor called SIRT1, a protein that helps extend cell life. and the Nrf2 signal pathway that helps fight free radicals. Including inhibiting NF-κB, which is the main cause of inflammation.

Summary of the article

Resveratrol has great potential to be used as an "adjuvant" or alternative medicine for the treatment and prevention of stroke in the future. Because the target at the molecular level can be reached in many ways.