Research on the effects of resveratrol on reducing wrinkles and skin health in women aged 40 years and over is a randomized, controlled trial...

Summary of research on the effects of resveratrol on reducing wrinkles and skin health in women aged 40 years and over. This was a randomized, controlled trial (Randomized Placebo-Controlled Trial) for 8 weeks. The main points can be summarized as follows:

​1. Experimental method

Divide 134 healthy female volunteers (age 40+) into 4 groups:

​Group P/P: Take placebo + apply placebo cream

Group A/P: took resveratrol (75 mg/day) + placebo cream

Group P/A: take placebo + apply resveratrol cream (concentration 1.5%, apply 2 times a day)

Group A/A: Both ate and applied resveratrol.

​2. Important study results

Wrinkle reduction: The group that both "eats and applies" (A/A) saw the most obvious results. with a significant reduction in wrinkle scores compared to the placebo group during week 8 (wrinkles decreased approximately 11.9% from baseline).

Sebum: The group that applied resveratrol cream had significantly increased sebum levels in the U-zone. This helps moisturize the skin and reduces dryness that causes wrinkles.

Skin pigmentation (Pigmentation): found that the group that applied and the group that both ate and applied There was a greater decrease in skin pigmentation than the placebo group.

​Safety: The product is highly safe. Only minor and mild side effects were found.

​3. Summary of the research

Using resveratrol in both oral and topical forms together Most effective in reducing visible wrinkles. And using it topically helps improve the oil level on the skin to be more balanced. Suitable as an anti-aging skin care option for women aged 40 years and over.

Source: Frontiers in Aging (2025) and published in the PMC (PubMed Central) database.