“Resveratrol in Cancer Treatment with a Focus on Breast Cancer” published in the journal Current Molecular Pharmacology in 202...

Summary of the article “Resveratrol in Cancer Treatment with a Focus on Breast Cancer” published in the journal Current Molecular Pharmacology in 2023 discusses the role of “Resveratrol” (Resveratrol), which is a polyphenol substance from plants. in the prevention and treatment of cancer Focusing mainly on breast cancer.

Summary of the main points of the article

1. What is Resveratrol?

Resveratrol is a natural antioxidant. It has many features such as

- anti-inflammatory

- Protect cells from damage

- Slow down cell degeneration

- Helps prevent cancer.

Researchers are very interested in this substance. Because it was found that it can act on many processes of cancer cells at the same time.

2. The mechanism by which Resveratrol helps fight breast cancer

The article states that Resveratrol affects several signaling pathways in cancer cells, such as

☆ Inhibits the division of cancer cells.

Resveratrol can cause cancer cells. “Cell cycle arrest” causes cells to divide more slowly or stop growing.

☆ Stimulates the death of cancer cells (Apoptosis)

Helps stimulate cancer cells to enter the natural death process. Reduce the accumulation of abnormal cells

☆ Reduce inflammation

Chronic inflammation is associated with cancer. Resveratrol reduces several inflammatory factors, such as NF-κB and cytokines.

☆ Inhibits the creation of new blood vessels. (Anti-angiogenesis)

Cancer requires new blood vessels to grow. Resveratrol reduces the creation of blood vessels that supply the tumor.

☆ Reduce the spread of cancer.

There is information that Resveratrol inhibits the movement and spread of breast cancer cells. It involves the EMT pathway and autophagy signaling.

3. Use with chemotherapy

Related articles and research have found that Resveratrol may improve the effectiveness of certain chemotherapy drugs, such as:

-Doxorubicin

- Cisplatin

- Sorafenib

By reducing drug resistance and increases the sensitivity of cancer cells to drugs Reported example:

> Increase apoptosis of cancer cells

> Reduce spread

> Reduce the mechanism of multidrug resistance (MDR)

The article concludes that Resveratrol is a natural substance that “High potential” to help prevent and enhance breast cancer treatment through several mechanisms, such as

● Inhibits the growth of cancer cells.

● Stimulates cell death.

● Reduce inflammation.

● Reduce spread.

● Helps reduce drug resistance.