From PMC on "Therapeutic Potential of Resveratrol in Cancer and Neurodegenerative Disorders"
Summary of the article from PMC titled "Therapeutic Potential of Resveratrol in Cancer and Neurodegenerative Disorders"
Summary of important points about the benefits of the substance "Resveratrol" in the treatment of cancer and neurodegenerative diseases is as follows:
1. What is resveratrol?
Resveratrol is a phenolic compound in the Stilbenoid family that is found mainly in the skin of red grapes, mulberries, and some plants. Its outstanding feature is that it is an antioxidant. (Antioxidant) and anti-inflammatory substances (Powerful Anti-inflammatory)
2. Potential to fight cancer (Cancer)
Resveratrol exhibits cancer-suppressing mechanisms in three main stages:
Chemoprevention: Helps protect DNA from destruction by carcinogens. and reduce inflammation that is a trigger for cancer
Growth inhibition: inhibits the process of cancer cell division (Cell cycle arrest) and stimulates abnormal cell death (Apoptosis).
Prevention of proliferation: inhibits the formation of new blood vessels. (Angiogenesis) that grows cancer tumors and prevents the spread to other organs (Metastasis)
3. Potential in degenerative diseases of the nervous system (Neurodegenerative Disorders)
The article focuses on Alzheimer's disease. (Alzheimer's) and Parkinson's (Parkinson's):
Reducing the accumulation of toxic proteins: Helps reduce the formation of Amyloid-beta plaques and Tau proteins, which are the main causes of Alzheimer's disease.
Protecting neurons: Reduces oxidative stress in the brain and helps neurons be more resistant to damage.
Stimulating Autophagy: Helps cells get rid of waste or damaged proteins better.
4. Important molecular mechanisms
One of the most prominent mechanisms is the activation of Sirtuins (specifically SIRT1), genes associated with youthfulness. cell repair and energy metabolism which has a positive effect on both stopping cancer and slowing down brain degeneration.
Conclusion
Resveratrol is a natural substance. has a very high potential to become "Natural targeted medicine" for treating both cancer and brain disease