“Emerging Effects of Resveratrol on Wound Healing: A Comprehensive Review” (2022)

Summary of the article “Emerging Effects of Resveratrol on Wound Healing: A Comprehensive Review” (2022)

Overview of the article

This article is a review paper that collects research on Resveratrol, a polyphenol substance from plants (such as red grapes, mulberries), and how it plays a role in helping wound healing.

The highlight is

anti-inflammatory

Antioxidants

antibacterial

Slow down cell degeneration

The main mechanism that helps wounds heal faster

1. Reduce inflammation (Anti-inflammatory)

Resveratrol reduces inflammatory cytokines such as

TNF-α

IL-1β

COX-2

Helps control inflammation from being too much → Wounds heal faster.

2. Antioxidants (Antioxidant)

Reduce oxidative stress that causes wounds to heal slowly.

Protect cells from damage

Very important in diabetic wounds, chronic wounds

3. Stimulate the activity of important cells in the wound.

Fibroblasts (make collagen)

Resveratrol

Reduce excessive scar formation (scar/keloid)

Regulates pathway such as TGF-β/Smad

Helps the creation of new tissue to be more "balanced"

Keratinocytes (skin cells)

Stimulates proliferation and movement

Helps the skin close the wound quickly. (re-epithelialization)

Macrophages (immunity)

Reduce inflammation

Control the immune system to prevent too much tissue damage.

4. Antimicrobial and reduces infection

Has antibacterial effect

Reduces the risk of wound infection

5. Helps create new blood vessels (Angiogenesis)

Supports the delivery of nutrients to the wound

Makes tissues recover better

Format of use in work

Resveratrol isn't just for eating. But it was developed as:

hydrogel (wound dressing gel)

nanofiber scaffold

intelligent wound dressing