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“Potential mechanisms of action of resveratrol in prevention and therapy for mental disorders”

Overview of the article

This article is a review of research (2016–2023) that included data from both laboratory animals and humans. About the role of Resveratrol in preventing and helping treat psychiatric diseases such as

- Depression

- Bipolar

- Schizophrenia

- Alzheimer's

- Autism

Main mechanism of action (Mechanisms)

1. Reduce oxidative stress (Antioxidant)

Resveratrol reduces Reactive Oxygen Species (ROS) and increases antioxidant enzymes.

Reduce brain cell damage

- is an important mechanism Because many psychiatric diseases are related to “oxidative stress”

2. Anti-inflammatory of the brain (Anti-inflammatory)

Reduce inflammatory cytokines such as

TNF-α

IL-1β

IL-6

Reduces inflammation in the hippocampus and other parts of the brain.

- Helps reduce brain deterioration and emotional symptoms.

3. Balance neurotransmitters (Neurotransmitters)

Affects serotonin, dopamine

In bipolar disorder → helps reduce excessive dopamine levels

- Affects mood, happiness, and behavior

4. Stimulate the creation of brain cells (Neurogenesis & Neuroplasticity)

Increase BDNF (Brain-Derived Neurotrophic Factor)

Stimulates the creation of new nerve cells

- Helps restore the brain in depression and Alzheimer's.

5. Stimulate SIRT1 pathway

Resveratrol stimulates the SIRT1 protein.

Help:

Protect brain cells

Reduce apoptosis (cell death)

Increase cognitive function

- It is one of the very important molecular mechanisms.

6. Control cell death (Anti-apoptosis)

Reduce protein that induces apoptosis (BAX)

Increase cell protection protein (Bcl-2)

- Helps slow down brain degeneration

7. Adjust signaling pathways in the brain

such as

AMPK

PI3K/Akt

mTOR

NF-κB

- Involved with cell survival, inflammation and cellular energy.

Effects on important diseases:

Depression

Reduce anhedonia behavior

Reduces immobility (in laboratory animals)

Reduce stress hormone (cortisol)

Bipolar (Bipolar)

Reduce oxidative stress

Adjust dopamine signaling

Helps control mood swings

Schizophrenia

Helps reduce negative symptoms

Increase memory and learning

Safe when used together with medicine

Alzheimer's

Reduce amyloid-beta

Reduce neuroinflammation

Slow down cognitive decline

Brief summary

- Resveratrol helps the brain through 3 main functions.

Reduce inflammation

Reduce free radicals

revitalize brain cells

- Has the potential to help with many types of psychiatric disorders