“Inhibitory Potential of Resveratrol in Cancer Metastasis: From Biology to Therapy” (Research Review 2023):

Summary of the article “Inhibitory Potential of Resveratrol in Cancer Metastasis: From Biology to Therapy” (Research Review 2023):

Overview of the article

Cancer spread (metastasis) is the main cause of death in cancer patients (approximately 90% of patients).

Current cancer medicine often focuses on “Suppresses cancer tumors” but still cannot control the spread well.

Resveratrol (a substance from red grapes and mulberries) has been heavily studied as a possible way to stop the spread of cancer.

Mechanism by which Resveratrol inhibits proliferation

Resveratrol works in many ways. (multi-target) in metastasis processes such as:

1. Inhibit the process of metastasis (Metastatic cascade)

● Reduce invasion (invasion) of cancer cells.

● Reduce entry into the bloodstream. (intravasation)

● Reduces adhesion and colonization of new organs. (colonization)

2. Control important signaling pathways

- Inhibits cancer-related pathways such as

NF-κB, STAT3, PI3K/AKT, mTOR

- Reduce inflammatory substances (such as IL-6)

- Reduce the creation of new blood vessels (angiogenesis such as VEGF)

3. Reduce the activity of enzymes that help cancer spread.

such as MMP-2, MMP-9 (helps digest tissue to allow cancer to spread)

4. Regulate microRNA and genes

Modulate the expression of metastasis-related microRNAs

Brief summary

Resveratrol has great potential to Inhibits the spread of cancer by several mechanisms.