Summary of the article

“Resveratrol may mildly improve renal function in the general adult population: A systematic review and meta-analysis of randomized controlled clinical trials.”

Published in the journal Nutrition Research in 2023.

Research objectives

The researchers wanted to determine if supplementing with Resveratrol (a polyphenol found in red grapes, mulberries, etc.) could help improve Kidney function (renal function) or not?

Method of study

is doing

Systematic Review + Meta-analysis of RCTs

Collected research from 4 main databases.

A total of 32 studies were included.

Analysis of results in general adults (Not limited to kidney patients)

Indicators used to look at kidney function include:

BUN (Blood Urea Nitrogen)

Creatinine

GFR (Glomerular Filtration Rate)

Albumin

Total Protein

Uric Acid

Study results

Resveratrol has been found to help improve some key kidney indicators, including:

1. Significantly reduces BUN.

Average decrease –0.84 mg/dL

This indicates a better excretion of waste from the kidneys.

2. Significantly reduces Creatinine

Average decrease –1.90 µmol/L

It is a sign that kidney function may be improving.

3. Significantly increases GFR.

Average increase +7.58 mL/min/1.73 m²

A higher GFR means the kidneys are better at filtering waste.

Things that "don't change"

No clear effect was found on

Albumin

Total Protein

Uric Acid

Factors that make the results more evident

BUN clearly improved in the case

Short term use ≤ 12 weeks

Use a dose lower than 500 mg/day.

in diabetic patients

Creatinine clearly improved

Requires a higher size

Researcher's conclusion

Resveratrol has a “mild renal protective effect.”

But it is also a level of evidence.

“Low certainty”

Brief summary

Resveratrol slightly improves kidney function.

especially

Reduce BUN

Decrease Creatinine

Increase GFR

suitable to be

“Supplements for kidney health care”

Can communicate that

“Resveratrol has research supporting that it helps support kidney function.”

Especially in groups

Elderly people

Diabetic patients

People who want to take long-term kidney care

Preventive health group