Summary of the article

“Resveratrol's Anti-Cancer Effects through the Modulation of Tumor Glucose Metabolism”

From PubMed / Cancers Journal 2021

Research done at

Faculty of Medicine, Ludwig-Maximilian-University Munich, Germany

This article describes Resveratrol, a natural polyphenol found in red grapes. and mulberry Has the potential to help fight cancer. especially through “Disturbs the sugar metabolism of cancer cells” or Tumor Glucose Metabolism

The main idea of the article

1. Cancer cells like to use an abnormal amount of sugar (Warburg Effect).

Cancer cells have special characteristics:

Absorbs more glucose (sugar) than usual. Quickly converts sugar into energy through the Aerobic Glycolysis process.

Even with enough oxygen, a lot of “lactic acid” is produced.

This is called the Warburg Effect, which helps cancer.

Grow fast

Easy to spread

Avoid cell death (Apoptosis)

resistant to treatment

2. Resveratrol helps “cut off the energy” of cancer cells.

Resveratrol can reduce the use of sugar by cancer cells. By inhibiting many points such as

Reduces the delivery of glucose into cells

such as

GLUT1 (glucose transporter)

Inhibits important enzymes of Glycolysis

such as

HK (Hexokinase)

PFK1

PKM2

LDH

Reduce signals that stimulate cancer growth, such as

HIF-1α

PI3K/Akt/mTOR

NF-kB

Stimulate the death of cancer cells such as

p53

Bax

Caspase pathway

The result is

→ Cancer cells are “energy starved”

→ divides more slowly

→ More apoptosis occurs.

3. Resveratrol works in a multi-target way.

The article emphasizes that

Mono-target therapy for cancer often has poor results.

But Resveratrol has advantages:

It works in many ways at the same time.

Including:

anti-inflammatory

Resists the creation of new cancer blood vessels

anti-spread

Regulate metabolism

stimulate apoptosis

Therefore, it has the potential to be used in conjunction with main treatment such as

Chemotherapy

Radiotherapy

Targeted therapy

Brief summary

“Cancer requires sugar to survive.

Resveratrol helps cut off that energy,” so it helps.

Slow down the growth of cancer

reduce spread

Increases the death of cancer cells

Enhances the efficiency of the main treatment

It can be summarized as a simple idea:

“Resveratrol is not just an antioxidant.

But it also helps cut off the energy of cancer cells.”