: Antitumor Effects of Resveratrol Opposing Mechanisms of Helicobacter pylori in Gastric Cancer

Article summary: Antitumor Effects of Resveratrol Opposing Mechanisms of Helicobacter pylori in Gastric Cancer

(Anticancer effects of resveratrol against Helicobacter pylori in gastric cancer)

This article is a 2024 review in the journal Nutrients, explaining that Helicobacter pylori (H. pylori) is an important factor that causes stomach cancer and suggested that Resveratrol, a natural polyphenol It potently helps combat this carcinogenic process.

1. H. pylori and gastric cancer.

H. pylori is a Gram-negative bacterium that lives in the stomach. It was found that there were many infected people around the world. and is an important risk factor for stomach cancer. Although not everyone who is infected will develop cancer. But chronic infection clearly increases the risk.

Mechanisms by which H. pylori causes cancer

Infection causes:

destruction of the stomach lining

chronic inflammation

Oxidative stress

creation of new blood vessels (Angiogenesis)

Spread of cancer cells (Metastasis)

With important factors such as

CagA

VacA

Urease

Adhesion proteins such as BabA, SabA

which stimulates the secretion of inflammatory substances such as TNF-α, IL-6, IL-8 and increases ROS (Reactive Oxygen Species), resulting in abnormal cells and eventually cancer.

2. What is Resveratrol?

Resveratrol is a natural antioxidant. It is found in large amounts in:

Mulberry, red grape skin, etc.

There are outstanding features:

anti-inflammatory

Antioxidants

antimicrobial

Resists the growth of cancer cells

3. How does Resveratrol fight H. pylori?

Resveratrol works “oppositely” to the mechanism of H. pylori by

Reduce inflammation

inhibit

NF-κB

COX-2

TNF-α

IL-1β

IL-6

IL-8

Helps reduce chronic inflammation in the stomach.

Reduce oxidative stress

Eliminate free radicals

Reduce ROS

Stimulates the cell defense system through the Nrf2 pathway

It helps prevent DNA damage and reduces the chance of cancer.

Against H. pylori infection

Reduce biofilm formation

Reduce the survival of germs

Reduce infections in stomach cells

It has been reported that the use of 100 µM resveratrol can reduce ROS and IL-8 in infected gastric cells.

4. Resveratrol fights stomach cancer.

Resveratrol helps:

Inhibits the division of cancer cells

By reducing the work of

Cyclin D1

CDK4

Make cells stop dividing

Stimulates the death of cancer cells (Apoptosis)

Helps destroy cancer cells directly

Inhibits the creation of new blood vessels

This causes the tumor to lack nutrients and oxygen.

Reduce the spread of cancer

Reduces metastasis and disease progression.

Conclusion of the article

Resveratrol is a natural substance with high potential to

Reduces H. pylori infection

Reduce inflammation

Reduce oxidative stress

Inhibits the occurrence and progression of stomach cancer.

Therefore, it is an "add-on option" in preventing and treating stomach cancer. Especially in people at risk from H. pylori.

Short summary, easy to remember

H. pylori → Chronic inflammation → Oxidative stress → Stomach cancer

Resveratrol → Anti-inflammatory + Antioxidant + Disinfectant → Reduces the chance of cancer.