Summary of the article

“Molecular and biological functions of resveratrol in psychiatric disorders: a review of recent evidence”

Published in the journal Cell & Bioscience in 2020.

This article reviews research on Resveratrol and its role in psychiatric disorders such as depression, anxiety, autism spectrum disorder (ASD), and schizophrenia.

1. What is Resveratrol?

Resveratrol is a natural polyphenol. Found mostly in the skin of red grapes, mulberries, etc.

There are outstanding features:

● Antioxidants (Antioxidant)

● Anti-inflammatory. (Anti-inflammatory)

● Resists cell death. (Anti-apoptotic)

● Protects nerve cells. (Neuroprotective)

● Can cross the Blood-Brain Barrier (BBB) into the brain. Therefore, it has the potential to treat brain and psychiatric diseases.

2. Important mechanisms that help with psychiatric diseases

2.1 Reduce Oxidative Stress

Patients with psychiatric disorders often have

High free radicals (high ROS)

destruction of nerve cells

Mitochondrial damage

Resveratrol helps

Eliminate free radicals

Increase antioxidant enzymes such as Glutathione peroxidase.

Protecting the Mitochondria

Reduce brain cell damage

2.2 Reduce inflammation of the brain

Depression, anxiety, and schizophrenia are associated with

IL-1

IL-6

TNF-α

NF-kB

which is an inflammatory substance

Resveratrol helps

Inhibits NF-kB

Decrease TNF-α

Reduce NO

Reduce prostaglandins

Reduced microglial activation

Thus helping to reduce neuroinflammation.

2.3 Increase BDNF and brain function

BDNF is an important substance for

memory

learning

Emotion

nerve cell repair

Resveratrol helps increase

BDNF

SIRT1

AMPK

Wnt/β-catenin pathway

Makes the brain recover better and reduce symptoms of depression

3. Effects on various diseases

Depression

Resveratrol has been found to help

Reduce depressive behavior

Reduce inflammation in the hippocampus

Reduce apoptosis

Increase BDNF

Balancing serotonin/dopamine

Reduce stress hormone

Therefore it has similar effects. natural antidepressant

Anxiety

Help control

HPA axis

Cortisol

CRH

NF-kB pathway

Reduce chronic stress and reduce anxiety-like behavior

Autism Spectrum Disorder (ASD)

Found that

Reduce neuroinflammation

Adjust immune dysregulation

Reduce TLR/NF-kB pathway

increase social behavior

Some research has found that

Helps reduce hyperactivity

But it doesn't help.

irritability

social withdrawal

clearly

Schizophrenia (schizophrenia)

Resveratrol helps

Reduce oxidative stress

Increase BDNF

Prevent side effects from psychiatric drugs

Helps metabolic profile

Reduce movement disorders

The most important conclusion

Resveratrol = “Natural Neuroprotective Molecule”

Help through 4 main pillars

▪︎ Anti-inflammatory

▪︎ Antioxidants

▪︎ Protect brain cells

▪︎ Adjust the balance of neurotransmitters.

therefore has high potential to help

- Depressed

- Anxiety

- Autism

- Schizophrenia

“Resveratrol doesn't just take care of the heart.

But it also helps take care of your brain, mood, and mental health.”