: Neuroprotective Effects of Resveratrol in Ischemic Brain Injury

Article summary: Neuroprotective Effects of Resveratrol in Ischemic Brain Injury

From the MDPI journal (NeuroSci, 2021)

This article reviews the role of Resveratrol, a natural polyphenol found in red grapes. and mulberry that it can help protect the brain from ischemic brain injury (Ischemic Brain Injury / Ischemic Stroke) by emphasizing mechanisms for reducing inflammation Reduce oxidative stress and prevent the death of nerve cells

1. What is ischemic stroke?

It occurs when blood flow to the brain is reduced or interrupted, such as from a blockage in a cerebral artery. Causes the brain to lack oxygen and glucose, resulting in

The energy in the cells decreases.

High levels of free radicals (ROS) are produced.

increased inflammation

Nerve cells die

long-term neurological damage

Currently, the main treatment is to restore blood circulation. But there are still many limitations.

2. How does Resveratrol help protect the brain?

(1) Reduce inflammation of the brain

Resveratrol helps inhibit key inflammatory pathways such as

HMGB1

TLR4

MyD88

NF-κB

which stimulates the production of inflammatory substances such as

IL-1β

IL-6

TNF-α

The result is to reduce neuroinflammation. and reduce brain cell damage

(2) SIRT1 activation

SIRT1 is a protein involved in slowing cell degeneration.

Resveratrol increases the activity of SIRT1, causing

Reduce inflammation

Reduce cell death

Increase nerve cell repair

Reduced translocation of HMGB1 from the nucleus

Therefore helping the brain recover better.

(3) Antioxidants (Antioxidant)

Resveratrol reduces oxidative stress by

Reduce ROS

Increase antioxidant enzymes

Reduce lipid peroxidation

Prevents mitochondrial dysfunction

Makes nerve cells more resistant to ischemia

(4) Balancing the Gut–Brain Axis

Research has found that Resveratrol reduces post-stroke inflammation through balancing the immune system in the gut, for example.

Th17 / Treg

Th1 / Th2

Helps reduce systemic inflammation and protect the brain after ischemia.

3. The results of the experiment found that Resveratrol helps

Reduce the size of the brain dead area (infarct size)

Reduce brain swelling

Reduce the death of nerve cells.

Reduces microglia dysfunction

Restoring behavior and movement

Adjust the function of the blood-brain barrier

Demonstrate the potential to be neuroprotective agent clearly

Brief summary

Resveratrol is a natural substance that has the potential to help protect the brain from ischemia.

By helping

Reduce inflammation + Antioxidants + Prevent nerve cell death + Stimulate SIRT1

Therefore, it is an important guideline for developing stroke treatment in the future.