Summary of the article

A Review of Resveratrol as a Potent Chemoprotective and Synergistic Agent in Cancer Chemotherapy

(Frontiers in Pharmacology, 2019)

This article reviews research on Resveratrol, a natural polyphenol found in red grapes, mulberries, and some plants. Focusing on the role of Resveratrol in reducing side effects from chemotherapy. and helps enhance the efficiency of cancer treatment in combination with chemotherapy drugs

1. Purpose of the article

This is because cancer treatment with chemotherapy often causes severe side effects, such as

- Cardiotoxicity

- Hepatotoxicity

- Nephrotoxicity (Nephrotoxicity)

- Toxic to the digestive system

- drug resistance

- Recurrence of cancer

The researchers therefore studied whether Resveratrol can be both a "chemoprotective agent" and a "synergistic agent" in treating cancer.

2. What is Resveratrol?

Resveratrol or

3,5,4′-trihydroxy-trans-stilbene It is a natural substance that has important effects including:

+ Antioxidants (Antioxidant)

+ anti-inflammatory (Anti-inflammatory)

+ Antivirus

+ Antifungal

+ Slow down deterioration

+ Anticancer (Anticancer)

Especially the antioxidant effect Helps reduce cell damage from ROS (Reactive Oxygen Species), which is a major cause of toxicity from chemotherapy.

3. Resveratrol helps “prevent side effects” from chemotherapy.

3.1 Prevent heart toxicity

Chemotherapy drugs such as

Doxorubicin

Daunorubicin

Arsenic trioxide (As₂O₃)

often causes

Heart inflammation

Arrhythmia

heart failure

Resveratrol reduces ROS and increases SOD enzyme levels, reducing heart cell damage. And it is reported that Resveratrol is one of the most effective antioxidants.

3.2 Prevent kidney toxicity

Resveratrol helps

Reduce the accumulation of toxins from chemotherapy.

Reduce kidney damage

Helps remove toxins from the body

Thus reducing kidney damage from using chemotherapy.

3.3 Prevent liver toxicity

Resveratrol helps reduce

oxidative stress

inflammation of the liver

Liver cell damage from chemotherapy drugs

Thus reducing hepatitis from cancer treatment.

3.4 Prevent skin cancer from UV rays

Resveratrol can also help reduce skin damage from UVB and reduce the chance of skin cancer.

4. Resveratrol helps “strengthen” cancer treatment.

Resveratrol doesn't just prevent side effects. but also helps increase the efficiency of chemotherapy drugs by

Helps cancer cells become more sensitive to drugs.

Helps stimulate the death of cancer cells (Apoptosis)

Inhibits the division of cancer cells

Reduce the spread of cancer

Reduce the creation of new blood vessels in cancer tumors.

This makes chemotherapy drugs work better. and may help reduce the use of excessively high doses of the drug.

5. Important mechanism of Resveratrol

Resveratrol works through several routes, such as:

NF-κB

SIRT1

NQO1

CYP1B1

COX

IL-6

TNF-α

IL-1β

produce results

Reduce inflammation

Reduce DNA damage

Reduces the formation of estrogen-DNA adducts.

Inhibits the onset of cancer

Reduce chemotherapy resistance

Summary of the researcher

Resveratrol has great potential to be “Chemoprotective Agent”

Helps reduce side effects from chemotherapy and “Synergistic Agent”

Helps enhance the efficiency of cancer treatment

The shortest summary

“Resveratrol makes cancer treatment more effective.

and helps reduce damage from chemotherapy drugs.”

Therefore, it is a natural substance that has great potential in the future of contemporary cancer treatment.