“Role of resveratrol in the prevention and treatment of urological cancers: new perspectives on multiple molecular ta...

Summary of the article “Role of resveratrol in the prevention and treatment of urological cancers: new perspectives on multiple molecular targets and signaling pathways” from the Journal of Functional Foods (2025)

This article reviews research on Resveratrol, a natural polyphenol found in red grapes, berries, and some plants. By emphasizing the role of Prevent and help treat urinary tract cancers including:

■ Prostate cancer

■ Bladder cancer (Bladder cancer)

■ Kidney cancer (Renal cell carcinoma)

The researchers concluded that Resveratrol has important effects in both aspects. Antioxidants anti-inflammatory and anti-cancer As well as helping to increase the efficiency of chemotherapy drugs and reduce drug resistance.

The main points of the article

1. Resveratrol helps inhibit the occurrence and progression of cancer.

in prostate cancer

Resveratrol can

Reduce the activity of Androgen Receptor (AR), which is an important stimulator of prostate cancer.

Reduce the creation of new blood vessels in cancer tumors by reducing VEGF.

Reduce the spread of cancer cells by reducing MMP-9.

Stimulates cancer cell death (Apoptosis) through reducing Bcl-2 and increasing caspase-3 / caspase-9.

block the path PI3K/AKT/mTOR which is related to the growth of cancer cells

in bladder cancer

Resveratrol helps

Reduces angiogenesis under hypoxia by inhibiting HIF-1α.

Reduces communication between cancer cells and surrounding tissues.

Increased sensitivity to Cisplatin

Reduce drug resistance by affecting P-glycoprotein efflux

in kidney cancer

Resveratrol

Inhibits VEGF pathway

Inhibits mTOR pathway

Reduce the growth of cancer tumors

Reduce invasion and spread

Increased response to Paclitaxel by reducing survivin and PI3K/AKT signaling.

2. Helps increase the effectiveness of chemotherapy.

The article found that Resveratrol has a synergistic effect with medications.

Docetaxel

Paclitaxel

Cisplatin

5-Fluorouracil

make

Cancer cells are more sensitive to drugs.

Reduce drug resistance

Reduce the chance of recurrence

3. Important molecular mechanisms

Resveratrol works through several pathways such as

SIRT1 activation

NF-κB inhibition

Akt/mTOR suppression

FOXO activation

EGFR modulation

ERK1/2 inhibition

Androgen receptor suppression

miRNA/lncRNA regulation

Therefore, it is considered a substance that acts like Multi-targeted therapy does not work in just one area like many drugs.

A short summary

Resveratrol is a natural substance with high potential to “prevent + delay + promote treatment” of urinary tract cancer. Through inhibiting multiple signaling pathways and helping to reduce chemotherapy resistance.