Summary of the article

“Resveratrol Ameliorates Allergic Rhinitis by Activating SIRT1 to Disrupt the Mitochondrial ROS‐Inflammation Vicious Cycle”

Published in the Flavor and Fragrance Journal in 2026.

The main idea of the research

This article studies whether Resveratrol (Resveratrol) can help relieve How can we treat allergic rhinitis (Allergic Rhinitis (AR)? The mechanism is highlighted through the activation of SIRT1 protein, which plays an important role in regulating inflammation. oxidative stress and the function of mitochondria

AR disease is often associated with

Th2 inflammation

The creation of ROS (Reactive Oxygen Species) is abnormally high.

Mitochondrial damage

The vicious cycle “ROS → inflammation → increased ROS”

This research aims to prove whether Resveratrol can “break this cycle” or not.

Important mechanisms studied

Resveratrol → stimulates SIRT1 → reduces mitochondrial ROS → reduces inflammation → improves allergy symptoms

Especially related to

SIRT1

Nrf2/HO-1 antioxidant pathway

NF-κB inflammatory pathway

Macrophage shift towards M2 type (anti-inflammatory)

Method of study

Researchers use two models.

1. Cellular model

Experiment in cells

macrophages

nasal epithelial cells

By stimulating

LPS

OVA (ovalbumin)

To simulate inflammation caused by allergies

2.Animal model

Mice that were induced to develop AR with OVA were used.

To see the effect on actual symptoms, such as

Sneeze

rub nose

inflammation of the nasal mucosa

Important results

1. Reduce ROS clearly

Resveratrol reduces the accumulation of ROS within cells by approximately

↓ 45%

Ready to help restore mitochondrial membrane potential

This means that the mitochondria return to work better.

2. Reduce allergy symptoms in laboratory rats

Found that

Sneezing decreased by approximately 60%

Crushing is reduced by approximately 55%.

Clearly shown to relieve allergy symptoms.

3. Reduce inflammation of the nasal mucosa

Found that

inflammatory cell infiltration decreased

goblet cell hyperplasia decreased

mucosal thickening decreased

Brings the nasal mucosa back to near normal.

4. Confirm that SIRT1 is the key.

When using a SIRT1 inhibitor (EX527)

The beneficial effects of Resveratrol are clearly decreasing.

show that

“Resveratrol depends on SIRT1 to be fully effective.”

Conclusion of the research

Resveratrol can help relieve allergic rhinitis by

SIRT1 activation

Reduces mitochondrial ROS

Reduce oxidative stress

Reduce inflammation

Restoring the function of mitochondria

Reduces real allergy symptoms in experimental animals

Therefore, it may be a new way of development.

“Natural therapy for Allergic Rhinitis”

Especially in the form nutraceutical or functional ingredient

This research supports that

Resveratrol isn't just good for slowing down aging.

But it also helps with

Allergy

chronic inflammation

respiratory health

immune balance

mitochondrial health