“PI3K/Akt/mTOR signaling pathway: a critical signal transduction pathway in the anti-cancer effects of resveratrol” ต...

Summary of the article “PI3K/Akt/mTOR signaling pathway: a critical signal transduction pathway in the anti-cancer effects of resveratrol” published in the journal Heliyon in 2026 is a review article that collects evidence on the role of Resveratrol in anti-cancer. Emphasis is placed on inhibiting the signal path. PI3K/Akt/mTOR It is one of the important mechanisms that control the growth and survival of cancer cells.

The essence of the article

1. What is Resveratrol?

Resveratrol is a natural polyphenol found in red grapes and mulberries.

It has many biological activities, such as antioxidants. anti-inflammatory and anti-cancer

2. What is the PI3K/Akt/mTOR pathway?

It is a signaling system within the cell that controls

- cell division

- cell growth

- Protein creation

- Energy metabolism

- Avoiding cell death (Apoptosis)

When this route is overloaded It will promote cancer cells to grow faster, become resistant to drugs, spread easily, create new blood vessels to feed the cancer tumor.

3. Resveratrol fights cancer through PI3K/Akt/mTOR how?

The article concludes that Resveratrol can

- Inhibits PI3K

- Reduces the initial signaling that stimulates cancer cell growth.

- Inhibits Akt

- Causes cancer cells to lose their ability to survive and resist death.

- Inhibits mTOR

- Reduce protein creation and the division of cancer cells.

The result is

- Cancer cells stop dividing.

- Apoptosis occurs.

- Reduce spread and spread

- Increased sensitivity to chemotherapy drugs

4. Found results in many types of cancer.

The research collected in the article found positive results in

- Breast cancer

- Colon cancer

- Lung cancer

- Prostate cancer

- Stomach cancer

- Ovarian cancer

- Brain cancer (Glioblastoma)

- Pancreatic cancer

The main mechanism is to press the function of PI3K/Akt/mTOR and stimulate the death of cancer cells

5. Resveratrol can help reduce drug resistance.

The article emphasizes that Resveratrol helps.

- Restores the sensitivity of cancer cells to chemotherapy drugs.

- Reduce Chemoresistance

- Increase the effectiveness of some cancer drugs.

Therefore has the potential to be "Therapeutic supplements" combined with modern medicine

Summary for health use

Resveratrol from mulberry and other natural sources has anti-cancer potential. especially through inhibiting the path PI3K/Akt/mTOR which is central to the growth and survival of cancer cells Research shows good results in many types of cancer. and helps increase the efficiency of chemotherapy treatment