The article “Cardiovascular and Antiobesity Effects of Resveratrol Mediated through the Gut Microbiota” published in the journal Ad...

The article “Cardiovascular and Antiobesity Effects of Resveratrol Mediated through the Gut Microbiota,” published in the journal Advances in Nutrition, examines how resveratrol (a polyphenol found in red grapes and mulberries) affects heart health and reducing obesity. Emphasis on the role of Gut Microbiota

Summary of important points

1. The problem with Resveratrol is that it is poorly absorbed.

Although Resveratrol is highly beneficial But the body absorbs very little. Because it is metabolized quickly (rapid first-pass metabolism), the original substance in the blood is low.

However, research has found that

Microorganisms in the gut can convert Resveratrol into its active metabolites. and sometimes found in higher quantities than the original substance

2. Resveratrol helps balance the microorganisms in the intestines.

Especially in laboratory animals that eat high-fat diets (High-fat diet).

Resveratrol helps:

Increase the proportion of good bacteria

Reduce dysbiosis (loss of microbial balance)

adjust ratio Bacteroidetes : Firmicutes for better

(Obesity is often associated with too high Firmicutes.)

This reduces fat accumulation and chronic inflammation.

3. Helps strengthen the “intestinal wall” (Gut Barrier).

Resveratrol stimulates the formation of tight junction proteins.

The result is:

Reduce intestinal leakage

Reduce toxins from bacteria entering the bloodstream.

Reduce chronic low-grade inflammation (chronic low-grade inflammation)

which is an important cause of

Obesity

Diabetes

cardiovascular disease

4. Helps reduce the risk of heart disease and stroke.

Resveratrol helps reduce risk factors such as

Reduce blood fat

By helping to control cholesterol metabolism

Reduce TMAO

TMAO (Trimethylamine N-oxide) is a substance related to

Aortic stenosis

Hardened arteries

Heart disease risk

Adjusting the microbiota reduces TMAO formation.

5. Helps fight obesity (Anti-obesity Effect)

Resveratrol affects

satiety hormone

such as

GLP-1

Hormones regulating appetite

central energy metabolism

help

Get full faster

Reduce fat accumulation

increase energy consumption

Therefore, it tends to help reduce weight and obesity.

Researcher's conclusion

Resveratrol doesn't just work. Only direct "antioxidants" but also work through

“Gut Microbiota Axis”

is

Adjust microorganisms → Reduce inflammation → Adjust metabolism → Reduce obesity → Reduce the risk of heart disease.

Therefore it is a very interesting important mechanism.

Brief summary

Resveratrol is extracted from mulberries. Not only helps fight free radicals But it also helps balance the intestines, reduce inflammation, reduce fat, and reduce the risk of heart disease. and helps control weight through working with Gut Microbiota