“Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action”

Summary of the article “Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action”

This article reviews research on Resveratrol (RES), a natural polyphenol found in red grapes, blueberries, and pistachios. and mulberry Emphasis is placed on its role in treating breast cancer (Breast Cancer (BC) from the cellular level to molecular mechanisms.

1. Reasons for interest in resveratrol in breast cancer

Breast cancer is one of the most common cancers in women worldwide. and has a high death rate Especially in cases where drug resistance is present. spread and types that are difficult to treat, such as Triple-Negative Breast Cancer (TNBC).

Although main treatments such as chemotherapy, radiotherapy, surgery and immunotherapy will be effective But there are still limitations such as

Drug resistant

High side effects

Depress bone marrow function

Poor performance on TNBC

Therefore, there is interest in using natural substances such as resveratrol as an adjunct to treatment.

2. Resveratrol's anti-cancer mechanism

2.1 Inhibits the proliferation of cancer cells

Resveratrol helps

Reduce the division of cancer cells

Causes cells to stop during cell cycle arrest.

Reduce energy production of cancer cells

Reduced mitochondrial function

As a result, cancer cells grow more slowly and die more easily.

2.2 Stimulate the death of cancer cells (Apoptosis)

Resveratrol stimulates apoptosis through several routes, such as

Increases the activity of p53

Add Bax

Increase Caspase-3/Caspase-8

Reduce Bcl-2

Add Reactive Oxygen Species (ROS)

The result is that more cancer cells enter the programmed cell death process.

2.3 Reduce metastasis (Metastasis)

Resveratrol helps prevent

EMT (epithelial-to-mesenchymal transition)

Matrix Metalloproteinases (MMPs)

cell invasion

Migration of cancer cells

Therefore reducing the chance of spreading to

bone

lungs

Liver

brain

2.4 Control Autophagy

Autophagy may help or promote cancer, depending on the context.

Resveratrol can

Regulate autophagy

Reduce survival signaling

Helps increase treatment efficiency

especially in HER2-positive BC and metastatic BC

2.5 Inhibits Glycolysis (Warburg Effect)

Cancer cells use abnormally high levels of glycolysis to create energy.

Resveratrol helps

Reduces glycolysis

Disturbs energy generation

Reduce the growth of cancer tumors

It is considered another important mechanism for fighting cancer.

3. Resveratrol enhances the effects of chemotherapy drugs.

Resveratrol has been found to have a synergistic effect with drugs such as

Docetaxel

Paclitaxel

Cisplatin

Doxorubicin

Sorafenib

Raloxifene

help

Cancer cells are more sensitive to drugs.

Reduce drug resistance

increase apoptosis

Increase ROS

Reduce the use of chemotherapy drugs

Summary:

Resveratrol is a natural substance with high potential to help treat breast cancer. It can

inhibit division

Stimulate the death of cancer cells

reduce spread

Reduce drug resistance

Enhance the effects of chemotherapy