“Resveratrol supplementation improves endothelial function in chronic kidney disease” จาก American Physiological Society

Summary of the article “Resveratrol supplementation improves endothelial function in chronic kidney disease” from the American Physiological Society.

Objectives of the study

Patients with chronic kidney disease (CKD), especially those with diabetes. There is a high risk of cardiovascular disease due to decreased “endothelial function”.

The researchers therefore wanted to examine whether supplementing with resveratrol, a plant polyphenol, (found in red grapes, mulberries, etc.) Will it help restore blood vessel function?

Method of study:

It is an experiment.

randomized

double-blind

placebo-controlled

crossover study

in the patient

CKD stage 3

Have diabetes

Number of 28 people (actually random 25 people)

Average age 68 years

to eat

Resveratrol 400 mg/day

for 6 weeks

then compare with placebo

The main indicators are

Flow-Mediated Dilation (FMD)

It measures the ability of blood vessels to expand. which reflects the health of the lining of blood vessels

Results of the study:

Resveratrol was found to significantly improve endothelial function (the function of cells lining blood vessels) compared to placebo.

The FMD value improved significantly.

between-group comparison = 1.43 times

P value = 0.001

which means

Blood vessels respond better → reduce the risk of heart disease and stroke in the future.

Things that "don't change"

Even though FMD has improved,

eGFR (kidney function) value

HbA1c (accumulated sugar)

blood pressure

Vascular muscle response

has not changed significantly

shows that resveratrol Acts directly on "The lining of blood vessels"

It's not because of reducing sugar or blood pressure.

The mechanism that occurs

Resveratrol helps by

Reduce oxidative stress

Reduce inflammation

SIRT1 activation

Add eNOS

Increase Nitric Oxide (NO) formation

The result is

Blood vessels are more flexible.

Better blood circulation

Reduce cardiovascular risk

The important conclusion is

Resveratrol does not directly treat the kidneys, but helps “protect the blood vessels,” which is important in patients with chronic kidney disease, as most CKD patients die from it. “Cardiovascular disease” rather than end-stage kidney failure

This article supports that resveratrol plays a role in

● Blood vessel health

● Blood circulation

● Prevention of heart disease.

● Caring for diabetic patients

● Caring for the elderly

● Reducing risk in patients with chronic kidney disease.

Very suitable for use as “Research supports” in communicating health products Especially the resveratrol group. Extracted from mulberry