The Chronobiological and Neuroprotective Mechanisms of Resveratrol in Improving Sleep Research published on PubMed on ...

The Chronobiological and Neuroprotective Mechanisms of Resveratrol in Improving Sleep, published on PubMed in 2025.

Resveratrol in improving sleep According to biological time periods and neuroprotection

Abstract:

From statistics it is found that More than a third of the world's population experiences sleep problems, and approximately 10% of adults are diagnosed with insomnia. which is a proportion that increases every year Most of the medications currently used to treat insomnia were not developed specifically. But it was an accidental discovery. This often results in unavoidable side effects such as addiction, so there is an urgent need to find safer and more effective treatment options. Resveratrol, a natural polyphenol compound, Shows significant potential for improving insomnia symptoms Research shows that resveratrol's effects can occur through a number of biological processes. including resistance to cell death Antioxidants anti-inflammatory sleep rhythm regulation Modification of neurotransmitters (gamma-aminobutyric acid (GABA), DA, 5-HT, cortisol) and increasing levels of the neurotrophic factor BDNF. In addition, resveratrol's treatment for insomnia is closely linked to the SIRT1, AMPK, NF-κB, mTOR, PI3K/Akt, and MAPK signaling pathways. This article summarizes the mechanism of resveratrol in treating insomnia. To provide researchers with a deeper understanding of the mechanism of action. This will help in the development of new drugs with specific targets. and present new ideas and methods For the treatment of clinical insomnia