: Resveratrol as Anti-Cancer and Cardio Protective Agent: A Review published on Dec, 2021

Article summary: Resveratrol as Anti-Cancer and Cardio Protective Agent: A Review published Dec, 2021

This article discusses Resveratrol (Resveratrol), which is a type of natural polyphenol. Found in red grapes, mulberries and some plants. The chemical name is trans-3,5,4’-trihydroxystilbene This substance has received a lot of attention because it has important properties including anti-cancer and protecting the heart and blood vessels. (Cardio-protective)

1. Properties to prevent heart disease (Cardio-Protective Effects)

Cardiovascular disease is the leading cause of death worldwide. The important factors are

- Oxidative Stress

- Inflammation

- Obesity

- Type 2 diabetes

- high blood pressure

Resveratrol reduces these risks by: Key mechanisms:

- Effectively fights free radicals

- Reduce inflammation of blood vessels

- Reduce Endoplasmic Reticulum (ER) Stress

- Balancing the work of heart cells

- Reduce the risk of coronary artery disease.

- Reduce high blood pressure

- Reduce the risk of Stroke

- Helps reduce heart complications

The article also links to the French Paradox, which is that the French have a low rate of heart disease. Even when consuming high-fat foods This is believed to be related to drinking red wine that contains resveratrol.

2. Anti-Cancer Effects

Resveratrol plays an important role in inhibiting the birth and progression of many types of cancer cells, such as

- Breast cancer

- Colon cancer

- Lung cancer

- Liver cancer

- Stomach cancer

- Prostate cancer

- Ovarian cancer

- skin cancer

- Leukemia

- Bladder cancer, etc.

3. Anti-cancer mechanism

Resveratrol works through several mechanisms, such as

① Stimulate the death of cancer cells (Apoptosis)

Activate Caspase-3 and Caspase-9

Increase Bax/Bcl-2 ratio

Stimulate PARP cleavage

② Inhibits the division of cancer cells.

Stop the cell cycle (Cell Cycle Arrest)

Reduce Cyclin D1

Reduced PI3K/Akt signaling

③ Reduce inflammation

Inhibits NF-κB

Decrease COX-1 and COX-2

④ Reduce the spread of cancer.

Inhibits EMT (Epithelial-Mesenchymal Transition)

Reduce MMP-9

Reduces Metastasis

⑤ Increase the effect of chemotherapy drugs

Can be used in conjunction with chemotherapy drugs well.

Reduce side effects on the heart from chemotherapy drugs such as Doxorubicin.

4. Conclusion of the article

The researcher concluded that

Resveratrol is a natural substance with high potential for use as both a disease prevention agent. and supplements for the treatment of cancer and heart disease

Especially as

Complementary Medicine

Chemopreventive Agent

Cardio-Protective Supplement

and plays an important role in the future for

“Cancer Prevention + Heart Protection + Healthy Aging

Brief summary

“Resveratrol Extracted from mulberry It helps fight cancer, protects the heart, reduces inflammation, fights free radicals and delays aging, all in one substance.”

This is why resveratrol is called “The Anti-Cancer & Cardio-Protective Molecule”.