: Anti-cancer perspectives of resveratrol: a comprehensive review

Article summary: Anti-cancer perspectives of resveratrol: a comprehensive review

This article is a review of research on Resveratrol (Resveratrol), a natural polyphenol in the stilbene group found in red grape skins, mulberries, and some plants. By emphasizing the potential to Prevent and treat many types of cancer such as breast cancer, prostate cancer, liver cancer, lung cancer, pancreatic cancer, brain cancer, oral cancer. and ovarian cancer

The main points of the article

1. What is resveratrol?

Resveratrol has the chemical name 3,5,4-trihydroxystilbene It is a natural antioxidant. The most effective form is trans-resveratrol which has the ability to bind to receptors in cells and inhibit cancer-causing processes

2. Anti-cancer mechanism of resveratrol

Resveratrol works in several ways at the same time, including:

● Antioxidants (Antioxidant)

Helps reduce the occurrence of Reactive Oxygen Species (ROS), which is a stimulant of cell mutation and cancer.

Reduce lipid peroxidation

Increases the activity of antioxidant enzymes such as SOD, Catalase, Glutathione peroxidase.

● Stimulates the death of cancer cells (Apoptosis).

Helps cancer cells enter the natural death process.

Activate caspase-3, caspase-7, caspase-9

Reduce Bcl-2

Add Bax

As a result, cancer cells stop growing.

● Inhibits the division of cancer cells.

Inhibits Cell cycle and reduces the number of abnormal cells.

● Reduce the spread of cancer. (Anti-metastasis)

Helps inhibit the EMT (Epithelial-Mesenchymal Transition) process.

Increase E-cadherin

Reduce Twist1 and Vimentin

Thus reducing the progression and spread of cancer.

● Reduce inflammation.

Reduce inflammatory substances related to cancer, such as

IL-6

COX-2

STAT3

This reduces the environment that promotes cancer.

● Increase the efficiency of chemotherapy.

When used together with medicines such as

Cisplatin

5-Fluorouracil

It was found to have a synergistic effect, meaning the drug works better. and reduce drug resistance in cancer cells

3. Effects on each type of cancer

- Breast cancer

Reduced expression of genes involved in cancer growth

Effective against Triple-negative breast cancer (TNBC)

- Pancreatic cancer

Stimulate apoptosis and autophagy

Inhibits PI3K/Akt/mTOR pathway

- Liver cancer

Reduce the size of the cancer tumor

Reduce oxidative stress

- Ovarian cancer

Reduces glucose uptake and lactate production

Inhibits mTOR and Akt

- Brain cancer (Glioblastoma)

Reduced uPAR and ERK1/2

Inhibits the growth of cancer cells

Researcher's conclusion:

The researchers concluded that resveratrol is a natural substance with high potential to prevent and help treat cancer.

through multiple mechanisms simultaneously Both antioxidants reduce inflammation and stimulate the death of cancer cells. and reduce drug resistance

Therefore, it is considered a promising anti-cancer agent that is interesting for development into health supplements and treatments in the future.

Brief summary

“Resveratrol doesn't just kill cancer directly.

But it helps turn off many of the pathways that allow cancer to grow.”

Therefore suitable for both

>> Protection

>> Slowing down disease

>> Enhancing treatment efficiency