“Potential anticancer therapeutic targets of resveratrol and its role in the therapy of hepatocellular carcinoma” (Sc...

Summary of the article “Potential anticancer therapeutic targets of resveratrol and its role in the therapy of hepatocellular carcinoma” (ScienceDirect) published July, 2025

Overview of the article

This article is a review article that collects research on resveratrol. (Resveratrol), a polyphenol substance from plants (such as red grapes, mulberries) and its role in treatment Types of liver cancer Hepatocellular carcinoma (HCC), emphasizing molecular mechanisms and treatment targets.

Essence

1. Important properties of resveratrol:

Anti-cancer

Antioxidants

anti-inflammatory

It is a safe natural substance” and has the potential to be used as nutraceutical

2. Role in liver cancer (HCC)

(1) Prevent cancer in the early stages

Reduce oxidative stress and liver cell damage.

Helps prevent cell transformation into cancer.

(2) Stimulate the death of cancer cells (Apoptosis)

Causes cancer cells to "kill themselves"

Reduces the imbalance between cell division and death.

(3) Inhibits cancer growth

Reduce the division of cancer cells (proliferation)

Stop the spread movement and cell invasion

(4) Resists the creation of new blood vessels (Anti-angiogenesis)

Cancer must create new blood vessels to grow.

Resveratrol reduces this process → causing the tumor to grow more slowly.

(5) Reduce metastasis (Metastasis)

Inhibits the spread of cancer cells to other organs.

(6) Increase the efficiency of chemotherapy drugs

Makes cancer cells more sensitive to drugs

Reduce drug resistance problems

Has a synergistic effect with other drugs

3. Molecular mechanisms (Therapeutic targets)

Resveratrol works through several pathways such as:

PI3K/Akt/mTOR pathway → controls cell growth

MAPK pathway → related to division and response to stress

Apoptotic pathways (caspase) → stimulate cell death

Anti-inflammatory signaling → reduces inflammation that promotes cancer.

The highlight is that it “acts on many targets. (multi-target)” which is different from general drugs that usually focus on a single pathway.

Brief summary

Resveratrol is a natural substance with great potential in treating liver cancer by:

- Inhibits the occurrence and progression of cancer.

- Stimulates the death of cancer cells

- Reduces metastasis and new blood vessels.

- Increase the efficiency of chemotherapy drugs