Explaining the "smell of old people" in biology Must start from the actual cause first. Then connect to the role of Resveratrol...

Explaining the "smell of old people" in biology Must start from the actual cause first. Then connect it to the role of Resveratrol (Resveratrol) extracted from mulberries. What is the effect?

1. Origin of “Aging odor”

The special smell in elderly people is caused by important substances:

2-nonenal (trans-2-nonenal)

Main mechanism:

Caused by lipid peroxidation (oxidation of fat on the skin)

Especially ω-7 fatty acids will increase with age.

Enzymes and ROS (Reactive Oxygen Species) will accelerate the breakdown → forming aldehyde with a specific odor.

Summary:

“The smell of an old person = the result of oxidative stress + the deterioration of skin fat.”

2. Cellular mechanism of resveratrol extracted from mulberry

Resveratrol is a polyphenol from the stilbene family that has pronounced anti-aging effects.

>> (A) Reduce ROS → Reduce the cause of odor.

Increase antioxidant enzymes such as

SOD (Superoxide dismutase)

CAT (Catalase)

GSH (Glutathione)

Reduce ROS and lipid peroxidation

Results:

Reduce the occurrence of 2-nonenal

Reduces the "rancid smell" of the skin

>> (B) Stimulates SIRT1 (anti-aging gene)

Resveratrol activates important proteins:

SIRT1 (sirtuin)

AMPK (energy sensor)

Results:

increase mitochondrial function

Reduce cellular aging (senescence)

Reduce the accumulation of waste in cells

Connected with smell:

“Younger” skin cells → less abnormal fat production → less odor

>> (C) Stimulates Autophagy (waste elimination system)

Resveratrol stimulates “Cells eat themselves” (autophagy)

Helps eliminate protein/fat deterioration

Results:

Reduce odor precursors (oxidized lipids)

Reduce the accumulation of odor-causing substances on the skin.

>> (D) Reduce inflammation (Inflammation)

Inhibits NF-κB pathway

Results:

Reduce chronic inflammation that causes skin to deteriorate

Reduces production of lipid peroxides (2-nonenal formation)

3. Connect as an overall picture (Mechanism Map)

Aging → ROS ↑ → Lipid oxidation ↑ → 2-nonenal ↑ → Old person smell

(Resveratrol from Mulberry)

Anti ROS

SIRT1/AMPK activation

Increase autophagy

Reduce inflammation

Sum: ↓ lipid oxidation → ↓ 2-nonenal → ↓ odor of old people

4. Marketing Insight can be communicated “Science is easy to understand”

Not just "deodorizing"

but “reduce the cause at the cellular level”

Key message:

“Resveratrol is extracted from mulberries. Helps reduce the smell of old people By reducing the deterioration of skin fat from within.”

Brief summary

Resveratrol extracted from mulberry reduces odor in people through 4 main mechanisms:

>> Antioxidants → Reduce lipid oxidation

>> Stimulates SIRT1 → Slows cell aging

>> Stimulates autophagy → eliminates waste

>> Reduce inflammation → Reduce odor-causing substances

Therefore “reducing the occurrence of 2-nonenal” which is the cause of the smell.