Resveratrol (Resveratrol) extracted from mulberry in Dr.Vee products. There are many studies that explain the mechanism at the biomolecular level (m...

Resveratrol (Resveratrol) extracted from mulberry in Dr.Vee products has many studies explaining the molecular mechanism that helps protect the liver and kidneys, resulting in the liver enzyme values ​​SGOT, SGPT and kidney function values ​​eGFR tend to improve.

Below are some mechanistic explanations used in academic work.

Biomolecular mechanism of resveratrol on SGOT/SGPT and eGFR modulation.

1. Stimulation of SIRT1 pathway (Anti-aging & Cell Protection)

Resveratrol can stimulate enzymes.

Sirtuin 1 (SIRT1)

The results

Increases DNA repair of liver and kidney cells

Reduce apoptosis (cell death)

increase mitochondrial function

Clinical results

Reduce leakage of liver enzymes

→ AST (SGOT) values decreased.

→ ALT (SGPT) value decreases.

Kidney cells work better

→ Estimated Glomerular Filtration Rate improved.

2. Reduce Oxidative Stress in the liver and kidneys

Resveratrol is a very strong polyphenol antioxidant.

can stimulate transcription factor

Nrf2

Increases antioxidant enzymes such as

Superoxide dismutase

Catalase

Glutathione peroxidase

The results

reduce

lipid peroxidation

mitochondrial damage

So help

Prevent hepatitis

Prevent kidney deterioration

Improves SGOT, SGPT, and eGFR values

3. Inhibit inflammation of the liver and kidneys.

Resveratrol inhibits an important inflammatory pathway.

NF‑κB

When NF-κB decreases

will cause a decrease in cytokines such as

Tumor Necrosis Factor alpha

Interleukin 6

The result is

Reduce inflammation of hepatocyte (liver cells)

Reduce inflammation of the renal tubule (ureter).

make

SGOT SGPT decreased

eGFR improved

4. Increase fat metabolism in the liver (Anti-Fatty Liver)

Resveratrol Stimulant

AMP‑activated protein kinase

make

Reduce fatty liver

Reduce triglyceride accumulation

Increase beta-oxidation

The result is

Fatty liver decreased

SGOT SGPT values improved

5. Protect the kidneys (Nephron Protection)

Resveratrol reduces

glomerular oxidative damage

renal fibrosis

through restraint

Transforming Growth Factor beta

The result is

Reduce kidney fibrosis

increase glomerular filtration

Improves eGFR values

Summary of all mechanisms (Easy to understand)

Resveratrol from mulberry helps

Stimulates SIRT1 → Repairs liver and kidney cells.

Stimulate Nrf2 → increase antioxidant

Inhibits NF-κB → reduces inflammation

Stimulates AMPK → Reduces fatty liver.

Inhibits TGF-β → Reduces kidney fibrosis.

thus making

SGOT/SGPT decreased

eGFR improved