From the graph “Number of chronic kidney disease patients by region, fiscal year 2024” it is clear that Chronic kidney disease is an important public health problem in Thailand.
From the graph “Number of chronic kidney disease patients by region, fiscal year 2024” it is clear that Chronic kidney disease is an important public health problem in Thailand.
Overview of the worrying situation
Northeast There were a total of 519,618 patients.
Central region 383,242 people
Southern region 209,603 people
Northern region 206,471 people
Eastern region 98,990 people
Western region 76,007 people
When all regions are included It will be found that there are more than 1.4 million patients all over the country. Importantly, many patients are in stage 3 and stage 4, which are stages in which the kidneys have significantly deteriorated. And there is a high risk of developing to stage 5 (end-stage kidney failure) which requires dialysis or dialysis for life.
This reflects that chronic kidney disease is not an individual problem. But it is a burden on the public health budget. Severely affecting the quality of life of patients and their families
“Chronic kidney disease must not be You must be smart and know how to prevent it.” Chronic kidney disease often does not show symptoms in the early stages. Many patients become aware when more than 50% of their kidneys are damaged.
Therefore, “Prevention today” is the smartest strategy.
Important risk factors include:
Diabetes
high blood pressure
High blood fat
Chronic inflammatory conditions
Oxidative Stress
Dr.Vee resveratrol is extracted from mulberry. One of the natural extracts that has a lot of research supporting it.
Resveratrol is a polyphenol found in many plants. Especially in Mulberry There have been many scientific studies on its role in protecting the kidneys.
Molecular mechanisms involved in the prevention of chronic kidney disease.
Reduce oxidative stress (Antioxidant Effect)
Resveratrol stimulates the work of
SIRT1 pathway
Nrf2 signaling pathway
Resulting in increasing the production of antioxidant enzymes such as
Superoxide dismutase (SOD)
Catalase
Glutathione peroxidase
Helps reduce kidney cell damage from free radicals.
Reduce inflammation at the cellular level (Anti-Inflammatory)
Inhibit the stimulation of
NF-κB pathway
Reduce the secretion of inflammatory cytokines such as
TNF-α
IL-6
which is an important mechanism that causes chronic kidney deterioration
Reduce fibrosis in the kidneys (Anti-Fibrosis)
Resveratrol has been reported to
Inhibits TGF-β signaling
Reduce collagen accumulation in the kidney tissue.
Helps delay the occurrence of kidney hardening and kidney atrophy in the long term.
Protect the kidney unit (Podocyte Protection)
Helps maintain podocyte structure
Reduce the leakage of protein in the urine. (Proteinuria)
which is an important indicator of disease progression
scientific summary
Chronic kidney disease is based on
oxidative stress
chronic inflammation
Fibrosis
Mitochondrial abnormalities
Resveratrol is a natural substance that acts across multiple mechanisms at the molecular level. Therefore, it has received a great deal of attention in research. Nephroprotection
Important message
Thailand is facing more than a million people with chronic kidney disease. The correct concept is “Chronic kidney disease must not be You must be smart and know how to protect yourself.”
Starting to take care of your cells today means a better quality of life for the next 10–20 years.