Research “A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke” from PubMed / Heliyo...

Summary of the research article “A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke” from PubMed / Heliyon (2024) in easy to understand in Thai.

Article overview

This article is Academic review that collects and analyzes previous research on Resveratrol Potential (resveratrol) to protect the brain from ischemic stroke, which is a leading cause of death and disability worldwide.

Important Ingredients: What is Resveratrol?

Resveratrol is a natural polyphenol found in red grapes and berries.

Has antioxidant, anti-inflammatory, and anti-cell death properties. (anti-apoptotic)

Why should you be interested in Ischemic Stroke?

Cerebral ischemia is the leading cause of stroke (~68% of all) and has a very high mortality rate.

After an ischemic event There are many factors that increase brain cell death, such as inflammation, oxidative stress, and white blood cell infiltration.

Mechanism of action of resveratrol

The article emphasizes the action of resveratrol in cerebral ischemia. It comes from stimulating 2 important signaling pathways as follows:

1.

SIRT1 Pathway (Sirtuin-1)

Resveratrol stimulates SIRT1, a protein that helps:

Modulate the activity of PGC-1α and FOXO → Promote mitochondrial formation and cellular anti-stress response.

Reduce cell death and increases the survival of nerve cells

2.

NRF2 Pathway

NRF2 is a regulator of the oxidative defense response.

Resveratrol stimulates NRF2 → increases the production of anti-oxidation enzymes such as HO-1, NQO1 → helps eliminate ROS (reactive oxygen species) better.

Results from experimental studies

From the study it was found that:

Reduce the size of the area of dead brain tissue (infarct size)

Improves behavioral function and brain function

Controls blood flow in the brain

Reduces inflammation and oxidative stress

Helps maintain the integrity of nerve cells

Other important roles

In addition to the two main routes The report also points out that Resveratrol:

Helps maintain the function of the blood-brain barrier (BBB).

Reduces brain swelling and prevents the infiltration of proteins/molecules that cause cell damage.

Brief summary

Resveratrol has the potential to protect the brain from ischemia through reducing inflammation, oxidative stress. and cell death through stimulating the SIRT1 and NRF2 pathways