This study examined the effects of Resveratrol in combination with pharmaceutical care. (Pharmaceutical Care; PC) to patients with type 2 diabetes and complications...

Summary: This article examines the effects of Resveratrol in combination with pharmaceutical care. (Pharmaceutical Care; PC) for patients with type 2 diabetes and peripheral nerve complications (Diabetic Neuropathy)

Article information

Name: Impact of Resveratrol and Pharmaceutical Care on Type 2 Diabetes Mellitus and Its Neuropathic Complication: A Randomized Placebo Controlled Clinical Trial

Principal investigators: Gulabakh Sabir M. Amin et al.

Published in: Journal of Clinical Pharmacy and Therapeutics 2024

Study design: Randomized placebo-controlled clinical trial There is a control group and a placebo).

The purpose of the battle is to see that

1. Can Resveratrol help control blood sugar levels?

2. Does it help reduce symptoms of nerve degeneration from diabetes?

3. Does supervision by a pharmacist (PC) enhance treatment outcomes?

Method of study

120 patients with type 2 diabetes were divided into 4 groups.

group treatment

1 Resveratrol 500 mg/day

2 Placebo (placebo)

3 Resveratrol + Pharmaceutical Care

4 Placebo + Pharmaceutical Care

Study period 90 days

Evaluation Researchers measure:

- blood sugar level

-HbA1c

- Nerve pain

- Nerve conduction study

Neuropathy assessment scores such as MNSI and DN4

Study results

1. Better sugar control

Groups that received Resveratrol especially in combination with Pharmaceutical Care has:

● Fasting blood glucose decreases.

● HbA1c decreased significantly.

2. Nerve symptoms improved

Resveratrol has been found to help:

● Reduce numbness.

● Reduce burning pain.

● Reduced neuropathy score (MNSI, DN4).

● Improved nerve conduction.

3. Pharmaceutical Care plays an important role.

Pharmacist care helps:

- Reduce drug use problems (Drug Therapy Problems)

- Increase cooperation in treatment

- Help monitor symptoms and adjust patient behavior.

Conclusion of the research

Using Resveratrol at a dose of 500 mg/day in conjunction with supportive care Pharmaceutical Care:

▪︎ Helps control type 2 diabetes.

▪︎ Helps reduce nerve degeneration from diabetes.

▪︎ Can be used as a “complementary treatment” along with standard medicine.

Research strengths

■ It is a randomized placebo-controlled trial.

■ Both symptoms and neurological examination results are assessed.

■ Study the interaction of dietary supplements + pharmacist supervision.

Health meaning

This research supports the idea that Resveratrol has the potential to:

• Reduce inflammation.

• Reduce oxidative stress

• Protects nerves.

• Helps control sugar.

which corresponds to meta-analysis and other research in the latter period