With new knowledge in biological sciences Bringing humans one step closer to immortality (slowing down aging, no pain, no sickness)
With new knowledge in biological sciences Bringing humans one step closer to immortality (slowing down aging, no pain, no sickness)
Below is a description of a biological mechanism that can be used in both academic and health communication. It will be arranged to be easy to understand. But still maintaining scientific accuracy
1. Mechanism of mitochondrial degeneration (Mitochondrial Dysfunction) Mitochondria are The cell's “energy factories (ATP)”, mitochondrial degeneration is the starting point of aging and chronic diseases such as diabetes, heart disease, cancer, and brain disease.
1.1 Main causes of mitochondrial dysfunction
Oxidative Stress
Mitochondria are a source of free radicals (ROS). When too much ROS damages the mitochondrial membrane, proteins in the respiratory chain
mitochondrial DNA (mtDNA)
mtDNA damage
mtDNA does not have an efficient repair system like DNA in the nucleus.
When mtDNA is damaged → production of abnormal energy-producing enzymes → ATP decreases
Electron Transport Chain (ETC) malfunction. Incomplete electron transfer. Energy leakage → ROS increases → vicious cycle.
Reduction of the process of eliminating damaged mitochondria (Mitophagy) with age. The body doesn't get rid of damaged mitochondria properly. Damaged mitochondria accumulate → Cells become weak and inflamed.
2. Mechanisms for strengthening mitochondria (Mitochondrial Biogenesis)
Mitochondrial biogenesis is the process of creating new mitochondria. and restore the efficiency of the original mitochondria.
The key is stimulation. “Genes control cell energy”
2.1 The core of mitochondrial biogenesis
AMPK/SIRT1/PGC-1α axis
AMPK → Cell Energy Sensor
SIRT1 → longevity enzyme
PGC-1α → master regulator of mitochondrial formation
When this axis is stimulated, it occurs:
Increase the number of mitochondria
Increase the efficiency of ATP production
Increase cell stress tolerance
3. Mechanism of “Dr.Vee Resveratrol Extracted from Mulberry” on Mitochondria
Resveratrol extracted from mulberries is a stilbene polyphenol with high biological activity.
3.1 Prevent the deterioration of mitochondria
Direct antioxidant
Reduce ROS in mitochondria
Protects mtDNA and the mitochondrial membrane.
Reduce inflammation at the cellular level (Anti-inflammation)
Inhibits NF-κB
Reduces mitochondrial-associated inflammation (mito-inflammation)
Maintains mitochondrial membrane potential (ΔΨm)
Prevent energy leakage
Reduces stimulation of apoptosis (cell death)
3.2 Stimulate the creation of new mitochondria (Mitochondrial Biogenesis)
Resveratrol Dr.Vee works on “genes and enzymes”
Directly stimulates SIRT1
Resveratrol is a SIRT1 activator.
SIRT1 → deacetylate → PGC-1α
Increased expression of PGC-1α
Activate genes related to:
Creation of mtDNA
Creation of respiratory enzymes
Increasing the number of mitochondria
Indirectly stimulates AMPK
Put the cell into "Burn efficiently"
Increase the use of fat and sugar in a balanced way.
4. Biological results that occur in the body
When receiving mulberry resveratrol (such as Dr.Vee) regularly
Cell level:
↑ ATP
↓ ROS
↑ Number and quality of mitochondria.
Organ level:
Brain: Neurons resistant to degeneration
Muscles: Tough, strong, not tired.
Heart: Use energy efficiently.
Body level:
Slow down deterioration
Reduce the risk of chronic disease
Supports the concept of anti-aging in depth at the mitochondrial level.
5. Short summary of Key Message
Mitochondria dysfunction = root of degeneration
Resveratrol extracted from mulberry = cell regeneration switch
Resveratrol Dr.Vee
Prevents the deterioration of mitochondria.
Stimulates the creation of new mitochondria.
Restore cell power from the gene level to the body level