From ScienceDirect: “Role of resveratrol in the prevention and treatment of urological cancers: new perspectives...

Summary of articles from ScienceDirect's "Role of resveratrol in the prevention and treatment of urological cancers: new perspectives on multiple molecular targets and signaling pathways" in an easy-to-read format and easy to understand key points.

Article overview

This article reviews the role of resveratrol — a plant polyphenol with antioxidant and anti-inflammatory properties — in prevention and treatment. “urinary tract cancers” or urological cancers such as prostate cancer, kidney cancer (renal cell carcinoma), and bladder cancer (bladder) with a focus on related molecules and intracellular signals.

Important mechanisms of action of resveratrol

1. Resists cell growth and proliferation

Reduced MMP-2/MMP-9 expression associated with extracellular matrix destruction → Reduced cancer cell proliferation.

Inhibits VEGF/angiogenesis, which is required to form blood vessels to feed cancer tumors.

2. Stimulate cell death (Apoptosis)

Reduced signaling of proteins that help cells survive, such as Bcl-2

Increases the activity of caspase-3/-9 → cancer cells enter More "death programs"

3. Customize signal paths (Signaling Pathways)

Prostate Cancer

Inhibits PI3K/Akt/mTOR which stimulates cell growth

Reduce signaling through the Androgen receptor (AR) → Helps slow down the growth of prostate cancer.

Renal Cancer

Inhibits Akt/ERK1/2 that promotes tumor growth

Increase ROS and caspase activity to induce apoptosis.

Inhibits inflammasomes → reduces inflammation that promotes tumors

Bladder Cancer

Reduces miR-21 → reduces cell survival signals

Inhibits PI3K/Akt/mTOR → increases apoptosis and reduces cell proliferation.

4. Increase the effectiveness of chemotherapy

Resveratrol can:

cause cancer cells Respond better to chemotherapy, reduce drug resistance (chemoresistance), works with drugs such as docetaxel, paclitaxel to make treatment more effective