In-depth explanation about Biological mechanisms of resveratrol (Resveratrol) extracted from mulberry, 100% natural for protection and...

In-depth explanation about Biological mechanisms of resveratrol (Resveratrol) extracted from mulberry, 100% natural, helps prevent and inhibit the occurrence of many types of cancer.

1. Antioxidant Mechanism

Resveratrol is effective Eliminates free radicals (ROS), which is one of the causes of DNA damage that leads to mutations and cancer.

Stimulates antioxidant enzymes such as SOD (Superoxide Dismutase), Catalase and Glutathione Peroxidase.

Reduce chronic inflammation which is a condition that facilitates the growth of cancer cells

2. Inhibition of cancer cell growth signals (Anti-proliferative Effects)

Inhibits PI3K/AKT/mTOR pathway and MAPK/ERK pathway, which are important pathways that stimulate cancer cell division.

Inhibit the expression of Cyclin D1 and CDK4/6 that control the entry into cell division.

Stimulates the p53 tumor suppressor gene that helps repair DNA and stops cancer cells from dividing.

3. Stimulating programmed death of cancer cells (Apoptosis Induction)

Resveratrol increases the activity of Caspase-3, Caspase-8, and Caspase-9, key enzymes that trigger cell death.

Reduces the Bcl-2/Bax ratio causing cancer cells to enter the apoptosis process.

As a result, the growth of the tumor is controlled and some parts are destroyed.

4. Inhibition of tumor angiogenesis. (Anti-angiogenesis)

Resveratrol reduces the expression of VEGF (Vascular Endothelial Growth Factor).

This causes the tumor to lack nutrients and oxygen. unable to expand

Research has found that supplementing resveratrol with chemotherapy reduces drug resistance in some cancers.

5. Prevention of spread (Anti-metastatic Effects)

Inhibits the enzymes MMP-2 and MMP-9 (Matrix Metalloproteinases) that use cancer cells to decompose tissue to spread.

Reduce inflammation and adhesion of cancer cells to blood vessels.

Prevents spread to other organs.

6. Genetic and epigenetic regulation (Epigenetic Regulation)

Resveratrol affects Sirtuin-1 (SIRT1), which is involved in longevity and protection against cell degeneration.

Balances DNA methylation, reducing the chance of activating cancer-causing genes.

7. Types of cancer that have been studied for resveratrol Has the potential to prevent/cure

Breast cancer: inhibits estrogen receptor signaling

Colon cancer: reduces mucosal inflammation and stimulates apoptosis.

Liver cancer: reduces toxicity from carcinogens and reduces the creation of new blood vessels.

Lung cancer: inhibits cell growth and induces cell death.

Prostate cancer: inhibits the androgen receptor pathway.

Conclusion: Resveratrol from 100% natural mulberry has multiple mechanisms that work together. Including reducing free radicals, controlling cell division, stimulating the death of cancer cells, inhibiting new blood vessels, and preventing metastasis. and balance genes As a result, it is a natural substance with high potential to Prevent and help enhance cancer treatment.

For medical reasons, it has not been used as a standard of care. Because pharmaceutical companies don't want cancer patients to have an alternative to chemical drugs that have huge benefits.