The main points of the article “Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer”

Summary of the main points of the article “Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer”

Molecular mechanisms of resveratrol as an adjuvant to chemotherapy and radiotherapy in cancer.

Overview:

Cancer remains the leading cause of death worldwide, in part due to drug resistance or resistance to radiation. (chemoresistance and radioresistance)

Resveratrol (RSV), a plant polyphenol. (found in red grapes, mulberries, etc.) has antioxidant properties. anti-inflammatory and anti-cancer

Resveratrol has been studied as a Sensitizer that can make cancer cells respond better to chemotherapy and radiotherapy. It also helps protect normal cells from damage.

Features:

Resveratrol has various effects, such as antioxidants. Protects the heart and nervous system and anti-inflammatory

Anti-cancer mechanism of action:

Resveratrol works in many ways at the same time, such as:

Inhibits the division of cancer cells through pressing the signal PI3K/Akt/mTOR, Wnt, STAT3

Induces apoptosis by increasing Bax and decreasing Bcl-2.

Inhibiting NF-κB reduces invasion and metastasis.

Control epigenetics, such as reducing methylation of tumor suppressor genes (PTEN, BRCA1) and increasing methylation of cancer-causing genes.

Balancing microRNA and lncRNA involved in cancer growth and spread.

Resistance to cancer treatment:

Cancer cells can become resistant to treatment through several mechanisms, such as

Expression of anti-apoptosis proteins (Bcl-2, survivin)

p53 dysfunction

Activation of NF-κB, STAT3, EGFR, COX-2 pathways.

Transport of drugs out of cells (multidrug resistance proteins)

Hypoxia and DNA repair

The role of resveratrol in enhancing treatment

As a radiosensitizer: Resveratrol makes radiation more effective. Reduce tumor size and resistance It acts through induction of apoptosis, reduction of NF-κB, and suppression of HIF-1.

As a chemosensitizer: Resveratrol makes chemotherapy more effective by reducing MDR proteins, inhibiting Bcl-2 and STAT3, and enhancing the effects of many anticancer drugs (e.g. cisplatin, paclitaxel, doxorubicin).

Summary:

Resveratrol has great potential as a Natural substances enhance the efficiency of cancer treatment. Both chemotherapy and radiotherapy Through inhibiting signals related to chemotherapy resistance and radiotherapy resistance, therapy