Research from The University of Tokyo

Research from The University of Tokyo

Anti-cancer effects and cellular mechanisms of resveratrol

Anti-tumor effects and cellular mechanisms of resveratrol

Resveratrol (3, 5, 4'-trihydroxystilbene) is a phytoalexin present in a variety of plants. It has anti-oxidative and anti-inflammatory effects. and help reverse aging Ability to inhibit the proliferation of cancer cells Stimulates apoptosis. and inhibits the spread and invasion of cancer cells In this review The evidence of the anticancer effect and the molecular mechanism of resveratrol are summarized. First, we present the anti-invasive/metastatic effect of cancer cells. and the anti-inflammatory effects of resveratrol. Second, the main signaling pathways involved in these activities have been elucidated and summarized with studies on various malignant tumors. related Resveratrol not only induces cancer tumor cell death through the intrinsic/extrinsic pathway and cancer cell cycle arrest. But it also inhibits the invasion and metastasis ability of cancer tumors through modulating molecular targets involved in collagen degradation. These findings point to the potential antitumor effects of resveratrol against various types of cancer.