เรื่อง Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action

Summary of the article: Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action

Introduction:

Hepatocellular carcinoma (HCC) is a common cause of liver-related death. Risk factors include cirrhosis and hepatitis. Drinking alcohol, poor diet, and mycotoxins such as Aflatoxin B1

Treatment for early stage liver cancer may involve surgery or a liver transplant. But when the disease has entered the advanced stage Treatment still has limitations. and often found resistance to anticancer drugs

What is Resveratrol? Resveratrol is a natural polyphenol found in red grapes, mulberries, and some plants.

trans-resveratrol form It is a highly biologically active substance with antioxidant properties. Anti-inflammatory, anti-cancer and anti-aging (anti-aging)

Safe in general consumption sizes But absorption in the body is quite low.

Mechanism of action on hepatocellular carcinoma (HCC)

1. Early stage of the disease

Resveratrol inhibits mutations caused by free radicals.

Stimulates apoptosis (programmed cell death) through p53, Bax, caspases.

Inhibits cell division by repressing cyclin D1, CDKs and Akt/mTOR, MAPK, NF-κB signals.

2. Metastatic stage

Inhibits metastasis (metastasis) by reducing the activity of MMP-2, MMP-9 and inhibiting the HGF/c-Met pathway.

Inhibits angiogenesis (new blood vessel formation) by repressing VEGF and SP-1.

Reduces oxidative stress and inflammation by balancing antioxidant enzymes (SOD, GST, CAT, GPx) and reducing TNF-α, IL-6.

3. Enhance the immune system

Reduces the production of Treg and macrophage M2 that suppress the immune system.

Increase anti-cancer cytokines such as TNF-α, IFN-γ

4. Autophagy Induction

Stimulates Beclin1, LC3II and p53, causing cancer cells to enter the process of self-degradation.

Potential for use in combination with drugs

Chemosensitization: Increases the effectiveness of standard drugs such as Sorafenib, Paclitaxel, Cisplatin.

Synergism: Works with other natural extracts (such as Curcumin, Thymoquinone, Berberine) to increase cancer cell death and reduce the side effects of chemotherapy drugs.

Summary:

Resveratrol has great potential in preventing and treating liver cancer. Through several mechanisms, including antioxidant activity, stimulating apoptosis, inhibiting metastasis and angiogenesis, as well as synergizing with cancer drugs.