This diagram explains Cancer prevention mechanisms (chemopreventive mechanism) of Resveratrol (RESV) using the route...

This diagram explains Cancer prevention mechanisms (chemopreventive mechanism) of Resveratrol (RESV) using intracellular signal control routes as follows:

1. The role of resveratrol

Resveratrol is an antioxidant. (Antioxidant) found in some fruits such as red grapes and mulberries. It has properties that help reduce the risk of cancer through several mechanisms, including anti-inflammatory properties. reduction of free radicals and inhibiting carcinogens

2. Related routes

anti-inflammatory (Anti-inflammatory pathway)

RESV → Sirt1 → inhibits NF-κB and NLRP3.

NF-κB and NLRP3 are inflammatory activators.

When restrained Will reduce inflammation (inflammation), which is a risk factor for cancer.

RESV → MKP-1 → inhibits MAPKs → reduces NF-κB

Helps reduce signals that lead to inflammation

Reducing free radicals (Antioxidant pathway)

RESV → stimulates Nrf2.

Nrf2 is a transcription factor that activates antioxidant enzymes.

Helps reduce ROS (Reactive Oxygen Species), which are free radicals that damage DNA and increase the risk of cancer.

Inhibition of carcinogens (Anti-carcinogen activation)

RESV → inhibits CYPs

CYPs (cytochrome P450 enzymes) often turn certain substances in the body into carcinogens. (pro-carcinogens)

Inhibition of CYPs reduces carcinogenic activation.

3. Final results

Reduce inflammation

Reduce ROS (oxidative stress)

Reduce the stimulation of carcinogens

All of this leads to Reduce the risk of cancer (cancer prevention)

Brief summary:

Resveratrol prevents cancer through 3 main mechanisms —

1. Anti-inflammatory (inhibits NF-κB/NLRP3)

2. Reduce free radicals (via Nrf2)

3. Inhibits the conversion of substances into carcinogens (inhibits CYPs).