“Inhibitory Potential of Resveratrol in Cancer Metastasis: From Biology to Therapy” from the journal [MDPI Cancers] mentions...

Summary of the article “Inhibitory Potential of Resveratrol in Cancer Metastasis: From Biology to Therapy” from the journal [MDPI Cancers] mentions the potential of “Resveratrol” is a polyphenol found in red grapes and mulberries that inhibits the spread of cancer (Cancer Metastasis), which is the main cause of death from cancer.

The main points of the article

1. Cancer spread is a big problem.

Most cancer patients die from “Spread and spread” more than the original tumor The diffusion process consists of several steps such as

- Cancer cells invade tissue.

- enters the blood/lymph stream

- Evade immunity

- Go to the new organ.

- Create new blood vessels to feed the cancer tumor

The article points out that resveratrol can interfere with many of these processes.

2. The mechanism by which resveratrol inhibits cancer

● Inhibits the creation of new blood vessels. (Anti-Angiogenesis)

● Cancer must create new blood vessels to receive nutrients and grow. Resveratrol reduces VEGF signaling and angiogenesis. This makes it harder for the cancer to grow and spread.

● Inhibits EMT (Epithelial–Mesenchymal Transition).

EMT is a process that makes cancer cells more able to move and invade. Resveratrol reduces this change. Makes it harder for cancer cells to spread

● Reduce inflammation and cancer-promoting signals.

Resveratrol inhibits several signaling pathways involved in cancer, such as

▪︎ NF-κB

▪︎ PI3K/Akt/mTOR

▪︎ STAT3

▪︎ Wnt/β-catenin

▪︎ Hedgehog

▪︎ MAPK

These pathways are involved in the growth, inflammation, and spread of cancer.

3. Effective against many types of cancer

Pre-clinical research has found effects in many types of cancer, such as:

■ Breast cancer

■ Colon cancer

■ Stomach cancer

■ Ovarian cancer

■ Cervical cancer

■ Lung cancer

■ Prostate cancer

■ Bone cancer

It was found that it can reduce the division movement and invasion of cancer cells

4. Affects microRNA and cancer cell death.

Resveratrol can regulate several microRNAs involved in cancer, such as miR-34a, miR-155, miR-1305.

The result is that it stimulates the death of cancer cells (Apoptosis) and reduces metastasis.

Easy to understand summary

This article concludes that “Resveratrol” has high potential to help “Inhibits the spread of cancer” through several mechanisms, including reducing inflammation Reduce the creation of new blood vessels Inhibits the movement of cancer cells and stimulate abnormal cell death