If we don't do anything, 144,900 Thai people will die from cancer this year 2025.
If we don't do anything, 144,900 Thai people will die from cancer this year 2025.
New knowledge about natural mulberry extracts that are beneficial to cancer patients.
Resveratrol: A natural miracle substance with a complex anti-cancer mechanism.
Resveratrol, a polyphenolic compound found in some plants. Especially in red grapes and mulberry It is being widely recognized in the scientific community for its potential to fight and inhibit the growth of cancer cells. Through a variety of complex mechanisms at the cellular and molecular levels.
Resveratrol exerts its anti-cancer effects at various stages of the disease process. From the initiation, promotion, and spread of cancer cells. The main important mechanisms are as follows.
1. Antioxidant protection and inflammation reduction:
One of the outstanding properties of resveratrol is that it is a highly effective antioxidant. Able to capture and destroy free radicals This is an unstable molecule that can damage cell DNA, leading to mutations and the beginning of cancer cells. Resveratrol also has anti-inflammatory effects against chronic inflammation. which is another important risk factor that promotes the growth of cancer tumors.
2. Inhibiting the division and stimulating the death of cancer cells:
Resveratrol has the ability to control the cell cycle by blocking the division of cancer cells in different stages (G1/S and G2/M), preventing cancer cells from multiplying normally.
Moreover Resveratrol can also stimulate the process of "apoptosis," or programmed cell death. This is the body's natural mechanism for eliminating abnormal cells or cells that may develop into cancer. Resveratrol stimulates proteins involved in cell death, such as Bax and Caspase-3, ultimately causing cancer cells to be destroyed.
3. Inhibition of angiogenesis and metastasis:
Cancer cells need new blood vessels to carry nutrients and oxygen to the tumor. This process is called "Angiogenesis" Resveratrol can inhibit this process by reducing the expression of angiogenic stimulants VEGF (Vascular Endothelial Growth Factor) and MMPs (Matrix Metalloproteinases), causing the cancer to become malnourished and unable to continue growing.
Resveratrol also helps stop the spread of cancer cells (metastasis) to other organs of the body, which is the main cause of death in cancer patients.
4. Modulation of gene activity and cellular signaling pathways:
Molecular research has found that Resveratrol can affect the activity of several important genes and signaling pathways involved in cancer, including:
NF-κB (Nuclear Factor-kappa B): Inhibits the activity of NF-κB, a protein that controls inflammation and cancer cell survival.
STAT3 (Signal Transducer and Activator of Transcription 3): Reduces the activity of STAT3 that is involved in the division and spread of cancer cells.
PI3K/Akt/mTOR: Inhibits this signaling pathway. which plays an important role in the growth and metabolism of cancer cells
Wnt/β-catenin: controls signaling pathways involved in the development of colon cancer cells.
Sirtuins (SIRT1): Activates the activity of proteins in the sirtuins family, which play a role in DNA repair and regulating cell lifespan.
5. Increasing sensitivity to chemotherapy and radiotherapy:
What is interesting is Resveratrol can also work in conjunction with standard cancer treatments. It has been reported to increase the sensitivity of cancer cells to chemotherapy and radiotherapy. Makes the treatment more effective And at the same time, it helps protect normal cells from side effects of treatment as well.
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