“Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer” from the journal [Frontiers in Pharmacology]...

Summary of the article “Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer” from the journal [Frontiers in Pharmacology] discusses the role of “Resveratrol” in helping to increase the efficiency of cancer treatment both chemotherapy (chemotherapy) and radiotherapy (radiotherapy) by making cancer cells more sensitive to treatment and reduce drug resistance/radiation resistance

Summary of important points:

1. The main problem in cancer treatment is “drug resistance”.

Cancer cells can develop the ability to:

- Removes drugs from cells

- Repair damaged DNA

- Evade cell death (apoptosis)

- Adjust metabolism and biological signals to survive drugs and radiation.

As a result, chemotherapy and radiotherapy are less effective in many patients.

2. What is resveratrol?

Resveratrol is a natural polyphenol found in: red grapes, mulberries.

Effective:

● Antioxidants

● Anti-inflammatory.

● Anti-cancer

● Protect normal cells.

and has important abilities “Makes cancer cells more sensitive to drugs and radiation.”

3. Important mechanism by which resveratrol helps fight cancer

■ Inhibits the division of cancer cells.

■ Resveratrol helps stop the cell cycle in the G1/S phase, causing cancer cells to divide more slowly.

■ Stimulates cancer cell death.

■ Stimulates: apoptosis (programmed death).

■ autophagy

■ necrosis by increasing cancer suppressing proteins. and reduce proteins that help cells survive

■ Reduces inflammation and cancer-promoting signals.

■ Inhibits key pathways such as: NF-κB, PI3K/Akt, STAT3, COX-2.

which are the pathways involved in drug resistance and cancer growth.

4. Helps increase the efficiency of “radiotherapy”

The article reports that Resveratrol helps radiation destroy cancer cells better by:

☆ Increases DNA damage.

☆ Reduces DNA repair of cancer cells.

☆ Increases apoptosis.

☆ Reduce cancer stem cells (cancer stem cells). There is information in:

- Brain cancer

- Breast cancer

- Prostate cancer

- Lung cancer

5. Helps reduce chemotherapy resistance.

Resveratrol helps chemotherapy medicines work better, such as: Cisplatin, Temozolomide, Doxorubicin, Paclitaxel.

By:

> Reduce drug excretion from cells

> Reduce EMT (transformation that causes cancer to spread)

> Reduce cancer stem cells

> Increases oxidative stress in cancer cells

6. Important highlights

The article points out that Resveratrol has the following advantages:

- Acts by multiple mechanisms simultaneously

- Helps reduce the size or amount of chemotherapy drugs.

- Helps reduce side effects on normal cells

- has the potential to be “Adjuvants for cancer treatment”

Conclusion of the research The researchers concluded that resveratrol is “Additional aids” that have high potential in treating cancer Because it can make cancer cells respond better to drugs and radiation through many biological mechanisms.