If friends understand this part of the biomolecular mechanism Friends, you can have good health and a long life.

If friends understand this part of the biomolecular mechanism Friends, you can have good health and a long life.

Activation of the SIRT1 (Sirtuin 1) gene by resveratrol from mulberry is a biologically complex process. which involves intracellular communication at the molecular level Here is the detailed mechanism:

1. Overview of SIRT1

SIRT1 is the gene that encodes the enzyme. NAD⁺-dependent deacetylase, which plays a role in:

Controls cell aging (anti-aging)

DNA repair

Metabolic control

Prevent chronic diseases (such as cancer, diabetes, heart disease)

Normally, SIRT1 is in an inactive or repressed state, controlled through factors such as low NAD⁺ levels, oxidative stress, or chromatin remodeling.

2. The role of resveratrol (extracted from mulberry)

Resveratrol is a polyphenol with high antioxidant activity. which when entering the body can:

Stimulates SIRT1 expression

Increases NAD⁺ levels within cells

Helps open chromatin (Chromatin Remodeling)

Stimulates the SIRT1 gene transcription process

3. Detailed mechanism: SIRT1 activation by resveratrol.

3.1 Binding of resveratrol to SIRT1

Resveratrol can bind directly to SIRT1 (at the allosteric site).

As a result, the structure of SIRT1 changes → giving it the ability to increased deacetylation

This helps activate SIRT1 even at low NAD⁺ levels.

3.2 Increasing intracellular NAD⁺ levels

Resveratrol stimulates the enzyme AMPK (AMP-activated protein kinase).

AMPK → Increases energy metabolism → Increases NAD⁺

NAD⁺ → required for SIRT1 function (as a cofactor)

Increased NAD⁺ levels make SIRT1 more active.

3.3 Reduction of inhibition by SIRT1 suppressor protein

Resveratrol can reduce the expression of SIRT1 inhibitory proteins such as p53, NF-κB.

causing SIRT1 to be less inhibited and enable more work

3.4 Changes in chromatin structure (Epigenetic Regulation)

Resveratrol can affect histone modification.

Opens the chromatin structure in the promoter region of SIRT1

This allows RNA polymerase to easily read and decode SIRT1.

It's an epigenetic "gene" turned on.

3.5 Signaling through PGC-1α

Resveratrol → activates PGC-1α (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha).

PGC-1α → stimulates SIRT1 expression through co-signaling with AMPK.

Effective in increasing energy for cells and stimulate fat burning