Air pollution problems in Rayong province It is still far from being controlled within safety limits. Rayong people must find a way to take care of themselves.

Air pollution problems in Rayong province It is still far from being controlled within safety limits. Rayong people must find a way to take care of themselves.

To be knowledgeable about Biological properties of resveratrol (resveratrol) extracted from mulberry (Morus alba) to prevent and treat cancer. Summary of data from 7 reports from the PubMed database:

Academic research and reviews (all from PubMed/PMC)

1. Li et al. 2021 (Molecules; PMID 34946655)

Study of resveratrol (RES) and polydatin from mulberry (Morus alba L.).

– Found high amounts of resveratrol.

– Shows high antioxidant activity (DPPH, ABTS, ORAC)

– In HepG2 cells: increases CAT, SOD, GSH activities, reduces ROS, MDA and LDH.

→ Prevent damage from oxidative stress, which is one of the mechanisms involved in cancer.

2. Review of Anti‑Cancer Properties of Resveratrol (PMC, recent)

– Analyze anti-cancer effects in several ways (pleiotropic), including induction of apoptosis, cell cycle inhibition, and inflammation reduction.

→ Helps stop the initiation and growth of cancer cells.

3. Review of The Potential Use of Resveratrol for Cancer Prevention

– Summary of mechanisms of action such as modulation of miRNA, NF‑κB, p53, TGF‑β, and synergy with chemotherapy.

– Emphasizing that bioavailability is low, there is a concept of using nanoformulations to increase efficiency

4. Resveratrol and cancer: focus on in vivo evidence (PMC)

– Studies have shown that resveratrol protects against the initiation, promotion, and progression of carcinogenesis.

5. Resveratrol‑based combinatorial strategies for cancer management (PMC)

– Report on the use of resveratrol in Prostate cancer model

→ Reduce the incidence of adenocarcinoma. and inhibit the growth of cancer cells

6. Resveratrol oligomers for prevention/treatment of cancers (PMC)

– Reports of oligomeric derivatives of resveratrol (e.g. ε‑viniferin, α‑viniferin, Vaticanol C, etc.)

– Some oligomers have more anticancer effects than monomers through arresting cell cycle, induction apoptosis, and inhibiting proliferation/inflammation pathways.

7. Antioxidant Activity and Mechanism of Resveratrol and Polydatin (Li et al. same as work 1)

– but also includes experiments on HepG2 cells that focus on protection from oxidative damage.

→ Helps strengthen its role in preventing cancer through a mechanism to reduce oxidative stress by emphasizing the mechanism of antioxidant link with carcinogenesis.

Summary of the biological properties of Resveratrol from mulberry

Main features: Biological mechanisms. Summary of study results.

**Antioxidants (antioxidant)** Stimulates SOD, CAT, GSH, reduces ROS, MDA, helps protect cells from oxidative stress, which is a cause of cancer.

Inhibits cancer cells (anti‑proliferative) Arrest cell cycle, modulate p53, NF‑κB, TGF‑β

Induces apoptosis, stimulates caspases, reduces survivin, increases cytochrome C/Bax.

anti-inflammatory (anti‑inflammatory) inhibits COX, STAT1, NF‑κB pathways, reducing the environment that supports carcinogenesis.

Stimulates autophagy, reduces p62, promotes degradation and helps eliminate abnormal cells.

Enhances chemotherapy efficiency, increases apoptosis with gemcitabine, reduces resistance markers, inhibits drug‑resistance proteins, and increases PARP cleavage.

The oligomers are more stable, selective, potent. Some oligomers have IC₅₀ below 20 µM in many cell lines.

Summary

Resveratrol extracted from mulberry (in the form including polydatin) has several properties that support the prevention and treatment of cancer:

act as Rich in antioxidants

Inhibits the growth and increases apoptosis of cancer cells.

Reduces inflammation and stimulates autophagy to eliminate abnormal cells.

Enhances work with chemotherapy and reduces drug resistance

The ogligomers of resveratrol are more potent than the monomers.