[Frontiers] Anticancer Molecular Mechanisms of Resveratrol discusses the molecular mechanisms that cause “Resveratrol” (Resveratr...

Summary of the article [Frontiers] Anticancer Molecular Mechanisms of Resveratrol discusses the molecular mechanisms that cause “Resveratrol” (Resveratrol), which is a polyphenol substance in red grapes. and mulberry It has the potential to fight cancer in many ways.

Summary of important points

1. What is resveratrol?

Resveratrol is a substance in the stilbene family that plants produce to protect themselves from stress such as UV rays and fungi. It is found in some fruit plants. including mulberry

2. The main anticancer mechanism of resveratrol

- Inhibits the growth of cancer cells

Resveratrol can inhibit signals that stimulate cancer cell division, such as EGF-R, HER-2, and VEGF, slowing cancer cell growth and reducing the creation of new blood vessels that nourish the tumor.

- Stimulates the death of cancer cells (Apoptosis)

Stimulates the process of apoptosis or programmed death of cancer cells. Through the regulation of important proteins such as Bax, Bcl-2 and caspase pathways.

- Stop the cell division cycle

Resveratrol can cause cancer cells to "stop" at the G1/S or G2/M phase of the cell cycle, causing the cells to be unable to continue dividing.

- Reduce inflammation

Reduces the activity of NF-κB, COX-2, and TNF-α, which are involved in chronic inflammation and cancer development.

- Antioxidants

Helps reduce oxidative stress, reducing damage to DNA, lipids, and proteins in cells. which is one of the causes of cancer.

- Reduce the spread of cancer

Inhibits the EMT process and MMPs enzymes involved in cancer cell invasion and metastasis.

3. Helps increase the efficiency of chemotherapy drugs.

The article states that resveratrol has additive effects with certain chemotherapy drugs such as 5-Fluorouracil (5-FU), Cisplatin, Arsenic trioxide.

Makes cancer cells more sensitive to drugs and helps reduce the problem of drug resistance (multidrug resistance)

Brief summary

Resveratrol is a natural substance that has the potential to:

● Inhibits the growth of cancer cells.

● Stimulates the death of cancer cells.

● Reduce inflammation and free radicals.

● Reduce the spread of cancer.

● Increase the effectiveness of chemotherapy drugs.

Therefore it is considered as “multi-target anticancer agent” or anti-cancer agent that works by multiple mechanisms at the same time