Resveratrol, which is extracted from Mulberry, plays an important role in promoting cellular health. Especially...

Resveratrol, which is extracted from Mulberry, plays an important role in promoting cellular health. Especially in the field Stimulating the production of mitochondria (mitochondrial biogenesis) through the regulation of the SIRT1 gene and AMPK enzyme, which leads to the efficient activation of the main protein PGC-1α.

Biological Mechanism

1.

Resveratrol activates SIRT1

Resveratrol increases levels of NAD⁺ in cells → activates SIRT1 (Sirtuin 1).

SIRT1 deacetylates PGC-1α protein → making PGC-1α more stable and functional.

Increased PGC-1α activity → results in cells turning on the expression of genes related to mitochondrial biogenesis such as NRF-1, TFAM

2.

Resveratrol activates AMPK (AMP-activated protein kinase).

Resveratrol increases cellular energy use. or change in AMP/ATP ratio → stimulate AMPK

AMPK serves:

Stimulates PGC-1α expression

Helps stimulate the creation of energy (energy metabolism)

Increases fat and glucose metabolism

3.

SIRT1 and AMPK work together synergistically.

SIRT1 and AMPK can stimulate PGC-1α both directly and indirectly.

This results in the creation of new mitochondria. Increases cellular energy production and reduce oxidative stress (oxidative stress)

Summarized in order of events:

1. Resveratrol extract from Mulberry (Resveratrol extract from Mulberry)

2.

Activates SIRT1 (via NAD⁺) and AMPK (via energy expenditure) →

3.

Stimulates and enhances the function of PGC-1α →

4.

Increased expression of NRF-1, TFAM, and mitochondrial genes →

5.

add creation new mitochondria and improve cellular energy metabolism