This study investigated the effect of Resveratrol on the recovery of patients with acute ischemic stroke (Acute Ischemic Stroke) ...

Summary: This article studies the effect of Resveratrol on the recovery of patients with Acute Ischemic Stroke who received Alteplase (RT-PA) later than the standard golden period. that is, given within 3–4.5 hours after the onset of symptoms This was a randomized, double-blind, placebo-controlled trial. (double-blind placebo-controlled randomized trial)

Purpose of study

Want to see if resveratrol can help improve brain recovery and life after stroke? This was especially true in patients who received rt-PA later than the optimal time point.

Method of study

Total 60 patients

All received rt-PA within 3–4.5 hours of symptom onset.

Divided into 2 groups:

Resveratrol group: received 450 mg/day for 30 days and placebo group

Evaluate with:

NIHSS = Brain Symptom Severity Scale.

mRS = disability after stroke

Barthel Index = ability to use daily life

Resveratrol and Alteplase were used together in this trial.

Study results

1. Short-Term Encephalopathy Syndrome (NIHSS)

Both groups improved with time.

But resveratrol “did not” improve symptoms significantly more than placebo.

The summary is:

> Not clearly helping during short-term acute periods

2. Long-term recovery (3–6 months)

The group receiving resveratrol had:

mRS score improves → disability decreases

Higher Barthel Index → Help yourself more.

It means:

> Patients recover better in their daily life in the long term.

Mechanisms that are expected to be involved

The researchers explain that resveratrol may help:

● Reduce inflammation.

● Reduce oxidative stress.

● Protects the blood-brain barrier.

● Reduces brain cell damage after reperfusion.

Brief summary

This research found:

> Resveratrol does not immediately improve stroke symptoms, but it "improves long-term recovery" in patients who receive Alteplase later than the golden hour. Especially in the area of ​​ability to use daily life and reduce disability.