Things that the Thai medical community has never known It's new knowledge about cancer.
Things that the Thai medical community has never known It's new knowledge about cancer.
The following is an explanation of the biological mechanisms involved in Mitochondria in the cancer process, which is the main cause, and the role of resveratrol from mulberry. To strengthen the mitochondria To prevent cancer:
Biological mechanisms of cancer arising from defective mitochondria.
Mitochondria are important organelles whose main function is to produce energy (ATP) through the process of oxidative phosphorylation. and control programmed cell death (apoptosis)
When the mitochondria are not functioning properly There will be important effects on cancer including:
1. Unusual energy generation (Warburg effect)
Cancer cells often switch to anaerobic glycolysis. Even though oxygen is present (aerobic glycolysis)
Caused by abnormalities of the mitochondria. This causes energy from the TCA cycle and electron transport chain to decrease.
As a result, cancer cells divide faster because glycolysis provides the building blocks for building cells.
2. Creation of abnormally large amounts of free radicals (ROS).
Deteriorated mitochondria leak ROS.
ROS can damage DNA and cause mutations in genes that control growth (oncogenes and tumor suppressor genes).
3. Escape from the apoptosis process
Normal mitochondria release cytochrome c to trigger abnormal cell death.
But when it's defective Damaged cells are not eliminated. Leads to cancer cells becoming
Biological mechanism of mulberry resveratrol in strengthening mitochondria.
Resveratrol is a natural polyphenol found in mulberries. It has outstanding features to:
Stimulates the creation of new mitochondria. (mitochondrial biogenesis)
Reduce inflammation and provide antioxidants.
Controls abnormal cell death
Important biological mechanisms:
1. Stimulate SIRT1 (Sirtuin 1)
SIRT1 is a protein involved in regulating cell aging. and stimulate the activity of PGC-1α (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha)
PGC-1α is a key player in stimulating the formation of new mitochondria.
2. Increase AMPK (AMP-activated protein kinase).
Resveratrol increases AMPK activity, which speeds up metabolism and promotes energy production.
3. Reduce ROS and enhance the function of antioxidant enzymes.
such as SOD (superoxide dismutase), catalase
Helps reduce oxidative stress and damage to DNA.
Conclusion: Cancer can be prevented with scientific knowledge.
Mitochondrial function plays an important role in cellular health. Preventing cancer is not just about avoiding carcinogens, but can also:
Strengthen the mitochondria
Eliminate damaged cells before they become cancerous.
Reduce inflammation and ROS at the cellular level
Use natural substances that have biological effects, such as resveratrol extracted from mulberry. that is more effective than resveratrol from synthetic chemicals