Research the subject

Summary of research articles on

“Resveratrol inhibits the invasion and metastasis of colon cancer through reversal of epithelial-mesenchymal transition via the AKT/GSK-3β/Snail signaling pathway.”

Published in the journal Molecular Medicine Reports in 2019, studying the effects of “Resveratrol (Resveratrol)” on the spread of colon cancer.

The essence of the research

Aim: Researchers wanted to see if Resveratrol could:

Can it stop the progression and spread of colon cancer?

And through what mechanism does it work at the cellular level?

Important mechanisms studied

Cancer often spreads through a process known as metastasis.

EMT (Epithelial-Mesenchymal Transition) is when cancer cells:

- Loss of normal cell adhesion characteristics

- easily transformed into mobile cells

- Causes spread and spread to other organs

Research has shown that Resveratrol can “reverse” the EMT process.

● By inhibiting the signal path:

AKT/GSK, which is a route related to:

● Cancer cell growth.

● Movement

● Diffusion

Experimental Method The researchers used:

- Human colon cancer cells (SW480 and SW620)

- Tested both in test tubes and in rats.

Then give Resveratrol and check out:

- cell movement

- tissue invasion

- spread to the lungs

- Changes in EMT-related proteins

Study results

1. Resveratrol reduces the movement and spread of cancer cells.

Cancer cells moved and invaded tissues significantly reduced after receiving Resveratrol.

2. Resveratrol helps reverse EMT.

Found: Increased E-cadherin protein (helps cells stick together tightly)

Reduced N-cadherin and Snail (related to metastasis)

This indicates that the cancer cells have returned to resemble normal cells more closely.

3. Inhibits signal paths AKT/GSK-3β/Snail

Research has shown that Resveratrol reduces the activation of proteins: p-AKT, p-GSK-3β, Snail.

Thus, it helps stop the EMT process and reduces the spread of cancer.

4. In mice, lung metastasis was reduced.

Conclusion of the research

Resveratrol has the potential to:

■ Inhibits the progression of colon cancer.

■ Reduce spread.

and inhibit EMT through the AKT/GSK-3β/Snail pathway.

Therefore, it is a natural substance that is useful in developing as a supplementary treatment for cancer.