Information about cancer deaths in Thailand in 2025 is expected to be as high as 144,900 people, and higher than car accidents...

Data on expected cancer deaths in Thailand in 2025 are as high as 144,900 people, five times higher than car accidents, indicating the severity of the cancer problem now and in the near future. This emphasizes the need for research and development of effective prevention and treatment strategies.

Resveratrol is a natural polyphenol compound found in some plants, such as red grapes, peanuts, and mulberries. It is gaining a lot of attention for its properties in delaying aging, preventing and enhancing cancer treatment. It has a complex biological mechanism of action as follows.

Biological mechanism of action of resveratrol in delaying aging

Resveratrol works to delay aging through several mechanisms, including:

* Activation of Sirtuin proteins (specifically SIRT1): Sirtuin is a family of proteins that play important roles in regulating cellular metabolism, DNA repair and stress responses. SIRT1 activation by resveratrol can mimic the effects of caloric restriction, a method that has been shown to extend lifespan in many organisms. SIRT1 activation increases the efficiency of the mitochondria. Reduce damage from free radicals and promote cell survival

* Reducing Oxidative Stress: Oxidative stress is caused by the buildup of free radicals. which is a major cause of age-related cell and tissue damage. Resveratrol has powerful antioxidant properties. Helps eliminate free radicals and reduce damage to cells. which helps slow down the deterioration of cells and tissues

* Reducing inflammation: Chronic inflammation is a key factor in many age-related diseases. Resveratrol has anti-inflammatory effects by inhibiting inflammation-related signaling pathways such as NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells), which reduces inflammation in the body.

* Improving Mitochondrial Function: Mitochondria are the energy production house of the cell. Reduced mitochondrial function is a key feature of aging. Resveratrol improves mitochondrial function. Increases the creation of new mitochondria and reduce the accumulation of damaged cells All of which promote cell health and slow down aging.

* Controlling apoptosis: Resveratrol can help control apoptosis. This is the process of eliminating damaged or abnormal cells. Helps maintain tissue balance and prevent age-related deterioration.

Resveratrol's cancer prevention and treatment properties

Resveratrol exhibits anti-cancer properties at several stages of the cancer process. (carcinogenesis) from initial stages to progression and metastasis:

* Inhibition of cancer initiation (Tumor Initiation):

* Antioxidants: Reduces DNA damage caused by free radicals. It is a key factor in cell mutation and cancer initiation.

* Inhibition of enzymes involved in the activation of carcinogens: can inhibit the enzyme Cytochrome P450, which is the enzyme responsible for converting procarcinogens. (procarcinogen) to be an effective carcinogen.

* Increasing detoxification: Increases the activity of enzymes in Phase II detoxification pathways, which helps in eliminating carcinogens from the body.

* Inhibiting the promotion of cancer (Tumor Promotion):

* Inhibition of cancer cell proliferation: Resveratrol can inhibit cancer cell proliferation. By stopping the cell cycle in various phases such as G1/S phase, cancer cells cannot multiply.

* Induction of cancer cell apoptosis: Resveratrol can induce cancer cells to undergo apoptosis through several mechanisms, such as activating p53 (tumor suppressor gene) protein and regulating signaling pathways involved in cancer cell survival.

* Reducing inflammation: Reduces chronic inflammation in the tumor microenvironment, which is a factor promoting cancer growth and progression.

* Inhibiting the progression and spread of cancer (Tumor Progression, Invasion, and Metastasis):

*Inhibition of new blood vessel formation Angiogenesis: The formation of new blood vessels is essential for tumor growth and spread. Resveratrol can inhibit this process.

* Inhibition of cancer cell migration and invasion: Resveratrol can reduce the ability of cancer cells to move and invade neighboring tissues and spread to other parts of the body.

* Modulation of signaling: Resveratrol affects several signaling pathways involved in the growth, survival, and metastasis of cancer cells, such as Wnt/β-catenin, Hedgehog, MAPK, and NF-κB.

* Enhancing the effects of cancer treatment (Chemosensitization/Radiosensitization):

There is some research that suggests resveratrol may increase the sensitivity of cancer cells to chemotherapy and radiation. Makes treatment more effective and may help reduce side effects from some treatments.

Resveratrol from Mulberry

Mulberry is a natural source of resveratrol. In addition to the properties of resveratrol, Other polyphenolic substances Found in mulberries, they also help promote health and fight against aging and cancer.