Cancer problems in Thailand (2025 forecast)

Cancer problems in Thailand (2025 forecast)

There will be approximately 144,900 deaths from cancer per year.

More than died from Car accidents up to 5 times

Cancer is still The number 1 cause of death for Thai people.

Resveratrol (Resveratrol) is extracted from mulberry.

This natural substance has been continuously researched for the prevention and enhancement of cancer treatment.

Mechanism of action of resveratrol in fighting cancer.

1. Antioxidants (Antioxidant)

Free radicals (ROS) cause DNA abnormalities → mutations → cancer.

Resveratrol helps eliminate ROS.

Reduce cell mutation (Mutagenesis)

2. Inhibits the proliferation of cancer cells. (Anti-proliferation)

Inhibit abnormal cell cycles such as G1/S-phase arrest.

Suppress the activity of proteins that stimulate cell division, such as Cyclin D1, CDK4.

3. Stimulate the death of cancer cells (Induction of Apoptosis)

Stimulates the Intrinsic (Mitochondrial pathway) and Extrinsic pathway of programmed death (Apoptosis).

Increases Bax protein, reduces Bcl-2 → causes cancer cell death.

4. Inhibits the creation of new blood vessels. (Anti-angiogenesis)

Cancer cells need new blood vessels to supply them.

Resveratrol reduces the activity of VEGF (Vascular Endothelial Growth Factor).

Impedes the creation of blood vessels to supply the tumor → makes the tumor grow more slowly.

5. Reduce spread and spread. (Anti-metastasis)

Inhibits MMPs (Matrix Metalloproteinases) enzymes that help cancer cells spread.

Reduced secretion of E-cadherin suppression protein, which is involved in metastasis.

6. Anti-chronic inflammation (Anti-inflammatory)

Chronic inflammation is a trigger for cancer.

Resveratrol reduces the activity of NF-κB, COX-2, and TNF-α.

7. Improve communication signals in cells (Signal Modulation)

Activates SIRT1 → involved in DNA repair and anticancer.

Reduces the activity of STAT3, PI3K/Akt/mTOR pathway, which is the path that cancer cells use to grow.

Brief summary

Resveratrol is extracted from mulberry. Prevent and enhance cancer treatment by:

Reduce free radicals and mutations

Inhibits the division and stimulates the death of cancer cells.

Inhibits angiogenesis and proliferation.

Reduce inflammation that promotes cancer.