Chronic Kidney Disease (CKD) is usually caused by chronic inflammation and the gradual accumulation of kidney cell damage. Which behavior...

Chronic Kidney Disease (CKD) is usually caused by chronic inflammation and the gradual accumulation of kidney cell damage. Behaviors such as eating salty foods, frequently taking anti-inflammatory drugs (NSAIDs), consuming herbs, and synthetic chemical supplements — all of these things cause the kidneys to deteriorate faster.

So how does resveratrol extracted from mulberry work to "prevent" and "slow down" kidney deterioration?

Resveratrol is a powerful natural polyphenol. Antioxidants (Antioxidant) and anti-inflammatory (Anti-inflammatory) very high

Important mechanisms of resveratrol in protecting the kidneys

1. Antioxidants (reduce Oxidative Stress)

The kidney is an organ that uses a lot of energy. and thus cause a lot of free radicals Free radicals slowly damage kidney cells.

→ Resveratrol increases the activity of SOD (Superoxide Dismutase) and Catalase enzymes that eliminate free radicals.

→ Reduces Lipid Peroxidation (destruction of fat in kidney cells)

2. Reduce inflammation (Anti-inflammatory Effect)

Chronic inflammation (Chronic Inflammation) is an accelerator of kidney deterioration.

→ Resveratrol reduces the secretion of TNF-α, IL-6, NF-κB, which are inflammatory triggers in the kidneys.

→ Reduces the destruction of capillaries in the kidney (Glomerular injury)

3. Protect the blood vessels in the kidney (Endothelial Protection)

The kidneys depend on adequate blood supply. Resveratrol helps strengthen the kidney blood vessels by

→ Stimulates eNOS (Endothelial Nitric Oxide Synthase) → Increases NO (Nitric Oxide) production.

→ Improves blood vessel expansion, reduces pressure in the kidneys

(Very suitable for people with kidney impairment due to high blood pressure)

4. Inhibits fibrosis (Anti-fibrosis)

When chronic kidney inflammation There will be fibrosis in the kidneys.

→ Resveratrol inhibits the expression of TGF-β1 (Transforming Growth Factor Beta 1), which promotes fibrosis.

→ Helps slow down the hardening of the kidneys (Renal fibrosis).

5. Stimulate kidney cell repair (Pro-survival Signaling)

→ Resveratrol stimulates the SIRT1 and AMPK signaling pathways.

→ Helps stimulate energy metabolism more efficiently. and repair damaged cells

(SIRT1 is a protein involved in delaying aging. and extend cell life)

Simple summary

Resveratrol from Mulberry Helps protect the kidneys by:

Reduce free radicals

Reduce inflammation

Helps strengthen the kidney blood vessels.

Slow down the occurrence of kidney fibrosis.

Stimulates kidney cell repair

Resulting in slower kidney deterioration. And reduce the risk of entering end-stage kidney failure.